6n22
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mouse Protocadherin-15 EC1-2 BAP== | |
| - | + | <StructureSection load='6n22' size='340' side='right'caption='[[6n22]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6n22]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N22 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n22 OCA], [http://pdbe.org/6n22 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n22 RCSB], [http://www.ebi.ac.uk/pdbsum/6n22 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n22 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Narui, Y]] | ||
| + | [[Category: Sotomayor, M]] | ||
| + | [[Category: Calcium binding protein]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Hearing]] | ||
| + | [[Category: Mechanotransduction]] | ||
| + | [[Category: Stereocilia]] | ||
| + | [[Category: Tip link]] | ||
Revision as of 11:04, 13 November 2019
Crystal structure of mouse Protocadherin-15 EC1-2 BAP
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