6n47
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The structure of SB-2-204-tubulin complex== |
| - | + | <StructureSection load='6n47' size='340' side='right'caption='[[6n47]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6n47]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N47 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=KB4:4-(2-chloropyrido[3,2-d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one'>KB4</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n47 OCA], [http://pdbe.org/6n47 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n47 RCSB], [http://www.ebi.ac.uk/pdbsum/6n47 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n47 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arnst, K]] | ||
[[Category: Banerjee, S]] | [[Category: Banerjee, S]] | ||
| - | [[Category: | + | [[Category: Li, W]] |
[[Category: Miller, D]] | [[Category: Miller, D]] | ||
[[Category: Wang, Y]] | [[Category: Wang, Y]] | ||
| - | [[Category: | + | [[Category: Complex]] |
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Structural protein]] | ||
| + | [[Category: Tubulin]] | ||
Revision as of 11:05, 13 November 2019
The structure of SB-2-204-tubulin complex
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Categories: Large Structures | Arnst, K | Banerjee, S | Li, W | Miller, D | Wang, Y | Complex | Inhibitor | Structural protein | Tubulin
