6ps2

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'''Unreleased structure'''
 
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The entry 6ps2 is ON HOLD until Paper Publication
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==XFEL beta2 AR structure by ligand exchange from Timolol to Alprenolol.==
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<StructureSection load='6ps2' size='340' side='right'caption='[[6ps2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6ps2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PS2 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=JTZ:(2S)-1-[(1-METHYLETHYL)AMINO]-3-(2-PROP-2-EN-1-YLPHENOXY)PROPAN-2-OL'>JTZ</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLB:(2S)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLB</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ps2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ps2 OCA], [http://pdbe.org/6ps2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ps2 RCSB], [http://www.ebi.ac.uk/pdbsum/6ps2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ps2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Batyuk, A]]
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[[Category: Cherezov, C]]
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[[Category: Gati, C]]
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[[Category: Han, G W]]
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[[Category: Ishchenko, A]]
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[[Category: Iwata, S]]
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[[Category: Joti, Y]]
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[[Category: Li, C]]
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[[Category: Liu, W]]
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[[Category: Moraes, I]]
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[[Category: Nakane, T]]
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[[Category: Nango, E]]
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[[Category: Shiriaeva, A]]
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[[Category: Stauch, B]]
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[[Category: Tanaka, R]]
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[[Category: Tono, K]]
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[[Category: Weierstall, U]]
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[[Category: Zatsepin, N A]]
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[[Category: Alprenolol]]
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[[Category: B2ar]]
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[[Category: Beta2ar]]
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[[Category: Complex-lcp method]]
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[[Category: Drug design]]
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[[Category: Gpcr]]
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[[Category: Lcp-sfx]]
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[[Category: Ligand exchange]]
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[[Category: Membrane protein]]
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[[Category: Sbdd]]
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[[Category: Timolol]]
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[[Category: Xfel]]

Revision as of 11:08, 13 November 2019

XFEL beta2 AR structure by ligand exchange from Timolol to Alprenolol.

PDB ID 6ps2

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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