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6t28

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m (Protected "6t28" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6t28 is ON HOLD
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==Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 22 (CS640)==
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<StructureSection load='6t28' size='340' side='right'caption='[[6t28]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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Authors: Kraemer, A., Sorrell, F., Butterworth, S., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6t28]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T28 FirstGlance]. <br>
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Description: Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 22 (CS640)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M92:2-[(3~{S})-3-azanylpiperidin-1-yl]-4-[[2,6-di(propan-2-yl)pyridin-4-yl]amino]pyrimidine-5-carboxamide'>M92</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6t28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t28 OCA], [http://pdbe.org/6t28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t28 RCSB], [http://www.ebi.ac.uk/pdbsum/6t28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t28 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/KCC1D_HUMAN KCC1D_HUMAN]] Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.<ref>PMID:11050006</ref> <ref>PMID:15840691</ref> <ref>PMID:16324104</ref> <ref>PMID:17056143</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Calcium/calmodulin-dependent protein kinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
[[Category: Butterworth, S]]
[[Category: Butterworth, S]]
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[[Category: Edwards, A M]]
[[Category: Knapp, S]]
[[Category: Knapp, S]]
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[[Category: Edwards, A.M]]
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[[Category: Kraemer, A]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Structural genomic]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Bountra, C]]
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[[Category: Sorrell, F]]
[[Category: Sorrell, F]]
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[[Category: Kraemer, A]]
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[[Category: Complex]]
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[[Category: Inhibitor]]
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[[Category: Kinase]]
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[[Category: Sgc]]
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[[Category: Transferase]]

Revision as of 11:14, 13 November 2019

Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 22 (CS640)

PDB ID 6t28

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OCA

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