6uej

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m (Protected "6uej" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6uej is ON HOLD
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==Crystal structure of human zinc finger antiviral protein bound to RNA==
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<StructureSection load='6uej' size='340' side='right'caption='[[6uej]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6uej]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UEJ FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uej OCA], [http://pdbe.org/6uej PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uej RCSB], [http://www.ebi.ac.uk/pdbsum/6uej PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uej ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ZCCHV_HUMAN ZCCHV_HUMAN]] Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).<ref>PMID:18225958</ref> <ref>PMID:21102435</ref> <ref>PMID:21876179</ref> <ref>PMID:22720057</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Meagher, J L]]
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[[Category: Smith, J L]]
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[[Category: Antiviral protein]]
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[[Category: Rna binding domain]]
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[[Category: Zap]]
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[[Category: Zinc finger antiviral protein]]

Revision as of 11:16, 13 November 2019

Crystal structure of human zinc finger antiviral protein bound to RNA

PDB ID 6uej

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