6crd
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==INFLUENZA VIRUS NEURAMINIDASE SUBTYPE N9 (TERN) with tetrabrachion (TB) domain stalk== | |
| + | <StructureSection load='6crd' size='340' side='right'caption='[[6crd]], [[Resolution|resolution]] 2.57Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6crd]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43588 Atcc 43588]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CRD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CRD FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[7nn9|7nn9]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2280 ATCC 43588])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6crd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6crd OCA], [http://pdbe.org/6crd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6crd RCSB], [http://www.ebi.ac.uk/pdbsum/6crd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6crd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The influenza neuraminidase (NA) is a homotetramer with head, stalk, transmembrane and cytoplasmic regions. The structure of the NA head with a stalk has never been determined. The NA head from an N9 subtype influenza A virus, A/tern/Australia/G70C/1975 (H1N9), was expressed with an artificial stalk derived from the tetrabrachion (TB) tetramerization domain from Staphylothermus marinus. The NA was successfully crystallized both with and without the TB stalk, and the structures were determined to 2.6 and 2.3 A resolution, respectively. Comparisons of the two NAs with the native N9 NA structure from egg-grown virus showed that the artificial TB stalk maintained the native NA head structure, supporting previous biological observations. | ||
| - | + | Structure of an Influenza A virus N9 neuraminidase with a tetrabrachion-domain stalk.,Streltsov VA, Schmidt PM, McKimm-Breschkin JL Acta Crystallogr F Struct Biol Commun. 2019 Feb 1;75(Pt 2):89-97. doi:, 10.1107/S2053230X18017892. Epub 2019 Jan 23. PMID:30713159<ref>PMID:30713159</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6crd" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Atcc 43588]] | ||
| + | [[Category: Exo-alpha-sialidase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: McKimm-Breschkin, J]] | ||
[[Category: Schmidt, P]] | [[Category: Schmidt, P]] | ||
| - | [[Category: Streltsov, V | + | [[Category: Streltsov, V A]] |
| - | [[Category: | + | [[Category: Artificial stalk]] |
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase-hydrolase]] | ||
| + | [[Category: Neuraminidase]] | ||
| + | [[Category: Sialidase]] | ||
| + | [[Category: Tetrabrachion]] | ||
| + | [[Category: Viral protein-hydrolase complex]] | ||
Revision as of 11:25, 13 November 2019
INFLUENZA VIRUS NEURAMINIDASE SUBTYPE N9 (TERN) with tetrabrachion (TB) domain stalk
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