117d

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[[Image:117d.gif|left|200px]]
[[Image:117d.gif|left|200px]]
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{{Structure
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|PDB= 117d |SIZE=350|CAPTION= <scene name='initialview01'>117d</scene>, resolution 2.550&Aring;
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The line below this paragraph, containing "STRUCTURE_117d", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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{{STRUCTURE_117d| PDB=117d | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=117d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=117d OCA], [http://www.ebi.ac.uk/pdbsum/117d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=117d RCSB]</span>
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'''CRYSTAL AND MOLECULAR STRUCTURE OF THE ALTERNATING DODECAMER D(GCGTACGTACGC) IN THE A-DNA FORM: COMPARISON WITH THE ISOMORPHOUS NON-ALTERNATING DODECAMER D(CCGTACGTACGG)'''
'''CRYSTAL AND MOLECULAR STRUCTURE OF THE ALTERNATING DODECAMER D(GCGTACGTACGC) IN THE A-DNA FORM: COMPARISON WITH THE ISOMORPHOUS NON-ALTERNATING DODECAMER D(CCGTACGTACGG)'''
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==About this Structure==
==About this Structure==
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117D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=117D OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=117D OCA].
==Reference==
==Reference==
Crystal and molecular structure of the alternating dodecamer d(GCGTACGTACGC) in the A-DNA form: comparison with the isomorphous non-alternating dodecamer d(CCGTACGTACGG)., Bingman C, Jain S, Zon G, Sundaralingam M, Nucleic Acids Res. 1992 Dec 25;20(24):6637-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1480485 1480485]
Crystal and molecular structure of the alternating dodecamer d(GCGTACGTACGC) in the A-DNA form: comparison with the isomorphous non-alternating dodecamer d(CCGTACGTACGG)., Bingman C, Jain S, Zon G, Sundaralingam M, Nucleic Acids Res. 1992 Dec 25;20(24):6637-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1480485 1480485]
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[[Category: Protein complex]]
 
[[Category: Bingman, C.]]
[[Category: Bingman, C.]]
[[Category: Jain, S.]]
[[Category: Jain, S.]]
[[Category: Sundaralingam, M.]]
[[Category: Sundaralingam, M.]]
[[Category: Zon, G.]]
[[Category: Zon, G.]]
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[[Category: a-dna]]
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[[Category: A-dna]]
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[[Category: double helix]]
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[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:26:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:27:00 2008''
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Revision as of 06:26, 2 May 2008

Image:117d.gif

Template:STRUCTURE 117d

CRYSTAL AND MOLECULAR STRUCTURE OF THE ALTERNATING DODECAMER D(GCGTACGTACGC) IN THE A-DNA FORM: COMPARISON WITH THE ISOMORPHOUS NON-ALTERNATING DODECAMER D(CCGTACGTACGG)


Overview

The crystal structure of the alternating dodecamer d(GCGTACGTACGC) (5'-GC) has been determined to a resolution of 2.55A using oscillation film data. The crystals belong to space group P6(1) 22, a = b = 46.2A, c = 71.5A with one strand in the asymmetric unit, and are isomorphous with a previously described non-alternating dodecamer, d(CCGTACGTACGG) (5'-CC). Refinement by X-PLOR/NUCLSQ gave a final R factor of 14.2% for 1089 observations. The molecule adopts the A-DNA form. The interchange of the terminal base pairs in the two dodecamers results in differences in the intermolecular contacts and may account for the differences in the bending. This dodecamer shows an axial deflection of 30 degrees, in the direction of the major groove compared to 20 degrees in 5'-CC and may be a consequence of additional contacts generated in 5'-GC by the interchange of end base pairs. The high helical axis deflection appreciably influences the local helical parameters. The molecule exhibits relatively high inclination angles, and has a narrow major groove. The helical parameters when described relative to the dyad-related hexamer halves of the molecule give more reasonable values. The crystal packing, local helical parameters, torsion angles, and hydration are described and also compared with the non-alternating 5'-CC dodecamer.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal and molecular structure of the alternating dodecamer d(GCGTACGTACGC) in the A-DNA form: comparison with the isomorphous non-alternating dodecamer d(CCGTACGTACGG)., Bingman C, Jain S, Zon G, Sundaralingam M, Nucleic Acids Res. 1992 Dec 25;20(24):6637-47. PMID:1480485 Page seeded by OCA on Fri May 2 09:26:42 2008

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