Penicillin-binding protein

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</StructureSection>
</StructureSection>
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==3D structures of penicillin-binding protein==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*'''Penicillin-binding protein'''
 
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**[[1qme]], [[1rp5]], [[2z2l]], [[5oau]] – SpPBP 2X – ''Streptococcus pneumoniae''<br />
 
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**[[1k25]], [[1pyy]] – SpPBP 2X (mutant) <br />
 
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**[[5u47]] - PBP 2X – ''Streptococcus thermophilus''<br />
 
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**[[2fff]] - SpPBP 1B<br />
 
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**[[2bg1]], [[2xd5]] - SpPBP 1B (mutant) <br />
 
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**[[2c6w]], [[2v2f]] - SpPBP 1A <br />
 
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**[[2wad]], [[2wae]], [[2waf]] – SpPBP 2B<br />
 
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**[[3vma]] – EcPBP 1B - ''Escherichia coli''<br />
 
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**[[6g5r]], [[6fzk]] – EcPBP 1B UB2H domain – NMR<br />
 
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**[[4bjp]] – EcPBP 3 residues 67-577<br />
 
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**[[4bjq]] – EcPBP 3 residues 88-165<br />
 
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**[[2ex2]] – EcPBP 4<br />
 
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**[[1nzo]], [[1nzu]] – EcPBP 5<br />
 
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**[[1hd8]], [[1nj4]], [[1sdn]] – EcPBP 5 (mutant) <br />
 
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**[[3it9]] – EcPBP 6<br />
 
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**[[5tro]] - SaPBP 1 dimerization and transpeptidation domains – ''Staphylococcus aureus''<br />
 
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**[[1mwr]], [[1vqq]], [[4bl2]], [[4bl3]], [[4cpk]] - SaPBP 2A (mutant) <br />
 
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**[[2olu]], [[3dwk]], [[5m1a]], [[5m19]], [[5m18]] – SaPBP 2<br />
 
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**[[3vsk]] - SaPBP 3<br />
 
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**[[1tvf]] – SaPBP 4<br />
 
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**[[6dz8]], [[6c3k]] – SaPBP 4 (mutant)<br />
 
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**[[1w5d]] – BsPBP 4A – ''Bacillus subtilis''<br />
 
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**[[3mfd]] – BsPBP 5*<br />
 
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**[[2oqo]] – AaPBP 1A – ''Aquifex aeolicus''<br />
 
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**[[3equ]] – NgPBP 2 – ''Neisseria gonorrhoeae''<br />
 
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**[[3eqv]], [[5ksh]] – NgPBP 2 (mutant) <br />
 
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**[[6p52]], [[6p53]] – NgPBP 2 transpeptidase domain<br />
 
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**[[6p56]], [[4u3t]] – NgPBP 2 transpeptidase domain (mutant)<br />
 
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**[[5u2g]] – HiPBP 1A – ''Haemophilus influenza''<br />
 
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**[[3a3d]] – HiPBP 4 <br />
 
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**[[3a3j]] – HiPBP 5<br />
 
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**[[3lo7]], [[3un7]], [[5crf]] – MtPBP A – ''Mycobacterium tuberculosis''<br />
 
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**[[3oc2]], [[3pbn]], [[6hr4]] – PaPBP 3 – ''Pseudomonas aeruginosa''<br />
 
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**[[3tg9]] – PBP – ''Bacillus halodurans''<br />
 
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**[[3udf]] – AbPBP – ''Acinetobacter baumannii''<br />
 
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**[[3zg7]] – LmPBP 4 – ''Listeria monocytogenes''<br />
 
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**[[5dvy]], [[5e31]] – EfPBP 2 – ''Enterococcus faecium''<br />
 
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**[[6bsq]] - EfPBP 4<br />
 
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**[[6g0k]] - EfPBP 5 (mutant)<br />
 
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**[[5lp4]] – HpPBP 2 – ''Helicobacter pylor''i<br />
 
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*Penicillin-binding protein complex with antibiotics
 
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**[[1qmf]], [[2z2m]], [[2zc3]], [[2zc4]], [[2zc5]], [[2zc6]], [[5oj1]], [[5oj0]], [[5oiz]] – SpPBP 2X + antibiotic<br />
 
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**[[1mwu]], [[1mwt]], [[1mws]] - SaPBP 2A (mutant) + antibiotic<br />
 
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**[[2uwx]] - SaPBP 1B (mutant) + antibiotic<br />
 
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**[[2olv]] - SaPBP 2 + antibiotic<br />
 
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**[[3zfz]], [[3zg0]], [[4dki]] - SaPBP 2’ + antibiotic<br />
 
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**[[3vsl]] - SaPBP 3 + antibiotic<br />
 
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**[[5txi]], [[5ty7]], [[5tw8]] - SaPBP 4 + antibiotic<br />
 
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**[[3hum]], [[3hun]], [[5ty2]], [[5tx9]], [[5tw4]] - SaPBP 4 (mutant) + antibiotic<br />
 
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**[[2c5w]] - SpPBP 1A + antibiotic<br />
 
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**[[2jch]], [[2je5]], [[2xd1]] - SpPBP 1B (mutant) + antibiotic<br />
 
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**[[2ex6]], [[2ex8]], [[2ex9]], [[2exa]], [[2exb]] - EcPBP 4 + antibiotic<br />
 
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**[[3beb]], [[3bec]], [[3mzd]], [[3mze]], [[3mzf]] - EcPBP 5 + antibiotic<br />
 
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**[[3ita]] - EcPBP 6 + antibiotic<br />
 
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**[[3fwl]], [[5hld]], [[5hlb]], [[5hla]], [[5hl9]] – EcPBP 1B + antibiotic<br />
 
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**[[3a3e]], [[3a3f]], [[3a3i]] – HiPBP 4 + antibiotic<br />
 
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**[[4oon]] – PaPBP 1A + antibiotic<br />
 
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**[[3ocl]], [[3ocn]], [[3pbo]], [[3pbq]], [[3pbr]], [[3pbs]], [[3pbt]], [[4kqo]], [[4kqq]], [[4kqr]], [[4l0l]], [[6un1]], [[6hr6]] – PaPBP 3 + antibiotic<br />
 
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**[[6hr9]] – PaPBP 3 (mutant) + antibiotic<br />
 
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**[[3nb6]], [[3nb7]] - AaPBP 1A + antibiotic<br />
 
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**[[3udi]], [[3udx]], [[3ue0]], [[3ue1]] - AbPBP + antibiotic<br />
 
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**[[3upn]], [[3upp]], [[5cxw]] - MtPBP A + antibiotic<br />
 
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**[[3upo]] - MtPBP A (mutant) + antibiotic<br />
 
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**[[3zg8]], [[3zg9]], [[3zga]] - LmPBP 4 + antibiotic<br />
 
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**[[6mkh]], [[6mki]], [[6bsr]] - EfPBP 4 + antibiotic<br />
 
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**[[6g88]] - EfPBP 5 + antibiotic<br />
 
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**[[6p54]], [[6p55]] – NgPBP 2 transpeptidase domain + antibiotic<br />
 
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*Penicillin-binding protein complex with boronic acid derivatives
 
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**[[1z6f]] – EcPBP 5 + boronic acid<br />
 
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**[[2y2g]], [[2y2h]], [[2y2i]], [[2y2j]], [[2y2k]], [[2y2l]], [[2y2m]], [[2y2n]], [[2y2o]], [[2y2p]], [[2y2q]] - SpPBP 1B + boronic acid derivative
 
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*Penicillin-binding protein complex with peptidoglycan
 
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**[[3itb]] - EcPBP 6 + peptidoglycan peptide<br />
 
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**[[2j9p]] - BsPBP 4A + peptidoglycan peptide<br />
 
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**[[3zg5]] - SaPBP + peptidoglycan analog<br />
 
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*Penicillin-binding protein complex with other inhibitors
 
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**[[4fsf]], [[4wel]], [[4wej]] - PaPBP 3 + inhibitor<br />
 
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**[[4wek]] – PaPBP 3 (mutant) + inhibitor<br />
 
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**[[5fgz]] – EcPBP 1B + inhibitor<br />
 
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**[[4cjn]] – SaPBP 2A + quinazolinine derivative<br />
 
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**[[6g9f]], [[6g9p]], [[6g9s]] – EcPBP 2 + inhibitor<br />
 
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**[[5lp5]] – HpPBP 2 + MREC <br />
 
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*PBP D-alanyl-D-alanine carboxypeptidase or DD-transpeptidase
 
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**[[1skf]] – StDADC - Streptomyces<br />
 
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**[[1es2]], [[1es3]], [[1es4]], [[1es5]], [[1esi]], [[1j9m]] – StDADC (mutant) <br />
 
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**[[1w79]], [[1w8q]], [[1w8y]] – AcDADC - Actinomadura<br />
 
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**[[2wke]], [[4ben]] – AcDADC + antibiotic <br />
 
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**[[2xk1]], [[2xln]], [[2y4a]], [[2y55]], [[2y59]], [[3zvt]], [[3zvw]], [[4b4x]], [[4b4z]] – AcDADC + boronic acid derivative <br />
 
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**[[2vgj]], [[2vgk]], [[2xdm]] – AcDADC + peptidoglycan analog <br />
 
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**[[3zcz]] – AcDADC + inhibitor <br />
 
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**[[4rye]] – MtDADC <br />
 
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**[[4ppr]] – MtDACB1 + antibiotic <br />
 
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**[[5fsr]] – EcDADC <br />
 
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**[[5j8x]] – EcDACA + boronic acid derivative <br />
 
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**[[6ntz]] – EcDADC + antibiotic <br />
 
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**[[6osu]] – DADC – ''Francisella tularensis'' <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:31, 14 November 2019

E. coli PBP 4 complex with the antibiotic ampicillin and glycerol 2ex6

Drag the structure with the mouse to rotate

References

  1. Spratt BG. Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12. Proc Natl Acad Sci U S A. 1975 Aug;72(8):2999-3003. PMID:1103132
  2. Beadle BM, Nicholas RA, Shoichet BK. Interaction energies between beta-lactam antibiotics and E. coli penicillin-binding protein 5 by reversible thermal denaturation. Protein Sci. 2001 Jun;10(6):1254-9. PMID:11369864 doi:http://dx.doi.org/10.1110/ps.52001
  3. Kishida H, Unzai S, Roper DI, Lloyd A, Park SY, Tame JR. Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics. Biochemistry. 2006 Jan 24;45(3):783-92. PMID:16411754 doi:10.1021/bi051533t

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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