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{{Sandbox_Reserved_JMeans}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
{{Sandbox_Reserved_JMeans}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
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==Your Heading Here (maybe something like 'Structure')==
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==Leadzyme Structure==
<StructureSection load='2LDZ' size='340' side='right' caption='Leadzyme Structure' scene=''>
<StructureSection load='2LDZ' size='340' side='right' caption='Leadzyme Structure' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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== History ==
== History ==
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Leadzyme was discovered by Uhlenbeck and co-worked in 1992. The discovery was by in vitro selection, which allows for an isolation and amplification of selected functional molecules. This method has been key in the discovery of numerous RNA and DNA catalysis. Leadzyme, or lead-dependent ribozyme, is among the smallest known catalytic RNAs.
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Leadzyme was discovered by Uhlenbeck and co-worked in 1992, while they were searching for RNAs that cleaved in the presence of lead <ref>PMID:9813122</ref> . The discovery was by ''in vitro'' selection, which allows for an isolation and amplification of selected functional molecules. This method has been key in the discovery of numerous RNA and DNA catalysis. Leadzyme, or lead-dependent ribozyme, is among the smallest known catalytic RNAs <ref>PMID:9813122</ref> .
== Function ==
== Function ==
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Leadzyme is a relatively small catalytic RNA. In the presence of Pb^2+, it catalyzes the cleavage of the C6-C7 phosphodiester bond <ref>PMID:9813122</ref> . This is accomplished via nucleophilic attack <ref>PMID:9813122</ref> . The resulting in a 2', 3'-cyclic phosphate and a 5'-hydroxyl terminus <ref>PMID:9813122</ref> . The first reaction, increases the Pb^2+ cleavage by 1100-fold rate <ref>PMID:9813122</ref> . The resulting products then trigger a second reaction, in which the product opens to a 3' mono-phosphate group <ref>PMID:9813122</ref> .
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something <ref>PMID:9813122</ref>
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== Disease ==
== Disease ==

Revision as of 15:48, 18 November 2019

This Sandbox is Reserved from September 14, 2021, through May 31, 2022, for use in the class Introduction to Biochemistry taught by User:John Means at the University of Rio Grande, Rio Grande, OH, USA. This reservation includes 5 reserved sandboxes (Sandbox Reserved 1590 through Sandbox Reserved 1594).
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
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Leadzyme Structure

Leadzyme Structure

Drag the structure with the mouse to rotate

References

  1. ↑ Hoogstraten CG, Legault P, Pardi A. NMR solution structure of the lead-dependent ribozyme: evidence for dynamics in RNA catalysis. J Mol Biol. 1998 Nov 27;284(2):337-50. PMID:9813122 doi:S0022-2836(98)92182-9
  2. ↑ Hoogstraten CG, Legault P, Pardi A. NMR solution structure of the lead-dependent ribozyme: evidence for dynamics in RNA catalysis. J Mol Biol. 1998 Nov 27;284(2):337-50. PMID:9813122 doi:S0022-2836(98)92182-9
  3. ↑ Hoogstraten CG, Legault P, Pardi A. NMR solution structure of the lead-dependent ribozyme: evidence for dynamics in RNA catalysis. J Mol Biol. 1998 Nov 27;284(2):337-50. PMID:9813122 doi:S0022-2836(98)92182-9
  4. ↑ Hoogstraten CG, Legault P, Pardi A. NMR solution structure of the lead-dependent ribozyme: evidence for dynamics in RNA catalysis. J Mol Biol. 1998 Nov 27;284(2):337-50. PMID:9813122 doi:S0022-2836(98)92182-9
  5. ↑ Hoogstraten CG, Legault P, Pardi A. NMR solution structure of the lead-dependent ribozyme: evidence for dynamics in RNA catalysis. J Mol Biol. 1998 Nov 27;284(2):337-50. PMID:9813122 doi:S0022-2836(98)92182-9
  6. ↑ Hoogstraten CG, Legault P, Pardi A. NMR solution structure of the lead-dependent ribozyme: evidence for dynamics in RNA catalysis. J Mol Biol. 1998 Nov 27;284(2):337-50. PMID:9813122 doi:S0022-2836(98)92182-9
  7. ↑ Hoogstraten CG, Legault P, Pardi A. NMR solution structure of the lead-dependent ribozyme: evidence for dynamics in RNA catalysis. J Mol Biol. 1998 Nov 27;284(2):337-50. PMID:9813122 doi:S0022-2836(98)92182-9
  8. ↑ Hoogstraten CG, Legault P, Pardi A. NMR solution structure of the lead-dependent ribozyme: evidence for dynamics in RNA catalysis. J Mol Biol. 1998 Nov 27;284(2):337-50. PMID:9813122 doi:S0022-2836(98)92182-9
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