Phosphoribosyltransferase

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== Structural highlights ==
== Structural highlights ==
The structure of the yeast OPRT contains the two reaction products: <scene name='52/525122/Cv/14'>orotate</scene> and <scene name='52/525122/Cv/15'>PRPP</scene><ref name="Gonza" />. <scene name='52/525122/Cv/17'>Mg coordination site</scene>. Water molecules are shown as red spheres. <scene name='52/525122/Cv/16'>Whole binding site</scene>.
The structure of the yeast OPRT contains the two reaction products: <scene name='52/525122/Cv/14'>orotate</scene> and <scene name='52/525122/Cv/15'>PRPP</scene><ref name="Gonza" />. <scene name='52/525122/Cv/17'>Mg coordination site</scene>. Water molecules are shown as red spheres. <scene name='52/525122/Cv/16'>Whole binding site</scene>.
 +
 +
==3D structures of phosphoribosyltransferase==
 +
[[Phosphoribosyltransferase 3D structures]]
</StructureSection>
</StructureSection>
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*'''Orotate phosphoribosyltransferase'''
*'''Orotate phosphoribosyltransferase'''
 +
**[[2pry]] - yOPRT – yeast<br />
**[[1oro]] - EcOPRT – ''Escherichia coli''<br />
**[[1oro]] - EcOPRT – ''Escherichia coli''<br />
**[[1j7j]] - StOPRT – ''Salmonella typhimurium''<br />
**[[1j7j]] - StOPRT – ''Salmonella typhimurium''<br />
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**[[3dez]] - OPRT – ''Streptococcus mutans''<br />
**[[3dez]] - OPRT – ''Streptococcus mutans''<br />
**[[2yzk]] – OPRT – ''Aeropyrum pernix''<br />
**[[2yzk]] – OPRT – ''Aeropyrum pernix''<br />
-
**[[2pry]] - yOPRT – yeast<br />
 
**[[3m3h]] - BaOPRT – ''Bacillus anthracis''<br />
**[[3m3h]] - BaOPRT – ''Bacillus anthracis''<br />
**[[3mjd]] - OPRT – ''Francisella tularensis''<br />
**[[3mjd]] - OPRT – ''Francisella tularensis''<br />
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*Orotate phosphoribosyltransferase complex
*Orotate phosphoribosyltransferase complex
-
**[[1sto]] – StOPRT + OMP<br />
 
-
**[[2prz]] - yOPRT + OMP<br />
 
**[[2qcn]], [[2wns]], [[3l0k]], [[3l0n]], [[3mo7]] – hOPRT + UMP derivative<br />
**[[2qcn]], [[2wns]], [[3l0k]], [[3l0n]], [[3mo7]] – hOPRT + UMP derivative<br />
**[[3mi2]] - hOPRT + pyrazofurin monophosphate<br />
**[[3mi2]] - hOPRT + pyrazofurin monophosphate<br />
**[[4hib]], [[4hkp]] - hOPRT + inhibitor<br />
**[[4hib]], [[4hkp]] - hOPRT + inhibitor<br />
-
**[[4rv4]] - BaOPRT + PRPP<BR />
+
**[[2prz]] - yOPRT + OMP<br />
**[[4wml]], [[4wn3]] - yOPRT + PRPP<BR />
**[[4wml]], [[4wn3]] - yOPRT + PRPP<BR />
-
**[[1opr]], [[1lh0]] - StOPRT + orotate + PRPP<BR />
 
**[[2ps1]] - yOPRT + orotate + PRPP<BR />
**[[2ps1]] - yOPRT + orotate + PRPP<BR />
 +
**[[1sto]] – StOPRT + OMP<br />
 +
**[[4rv4]] - BaOPRT + PRPP<BR />
 +
**[[1opr]], [[1lh0]] - StOPRT + orotate + PRPP<BR />
**[[5hki]] – MtOPRT + Fe-citrate – ''Mycobacterium tuberculosis'' <br />
**[[5hki]] – MtOPRT + Fe-citrate – ''Mycobacterium tuberculosis'' <br />
**[[5hkf]] - MtOPRT + PRPP<BR />
**[[5hkf]] - MtOPRT + PRPP<BR />
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*'''Hypoxanthine-guanine phosphoribosyltransferase'''
*'''Hypoxanthine-guanine phosphoribosyltransferase'''
 +
**[[1z7g]] - hHPRT <br />
**[[1nul]], [[1grv]] - EcHPRT <br />
**[[1nul]], [[1grv]] - EcHPRT <br />
**[[1dbr]] - TgHPRT – ''Toxoplasma gondii''<br />
**[[1dbr]] - TgHPRT – ''Toxoplasma gondii''<br />
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**[[2geb]] - TteHPRT (mutant) <br />
**[[2geb]] - TteHPRT (mutant) <br />
**[[1vdm]] - PhHPRT – ''Pyrococcus horikoshii''<br />
**[[1vdm]] - PhHPRT – ''Pyrococcus horikoshii''<br />
-
**[[1z7g]] - hHPRT <br />
 
**[[3h83]], [[3hvu]], [[3o7m]], [[4qyi]] - BaHPRT<br />
**[[3h83]], [[3hvu]], [[3o7m]], [[4qyi]] - BaHPRT<br />
**[[3acb]] - TtHPRT – ''Thermus thermophilus''<br />
**[[3acb]] - TtHPRT – ''Thermus thermophilus''<br />
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**[[4rqa]], [[4rqb]] – HPRT – ''Staphylococcus aureus''<br />
**[[4rqa]], [[4rqb]] – HPRT – ''Staphylococcus aureus''<br />
-
*Hypoxanthine-guanine phosphoribosyltransferase binary complex
+
*Hypoxanthine-guanine phosphoribosyltransferase binary complex with nucleotide
-
**[[1a98]], [[1a97]] - EcHPRT (mutant) + GMP<br />
 
-
**[[1g9s]] - EcHPRT + IMP<BR />
 
-
**[[1g9t]] - EcHPRT + GMP<br />
 
**[[1hmp]], [[2vfa]] - hHPRT + GMP<br />
**[[1hmp]], [[2vfa]] - hHPRT + GMP<br />
**[[3gep]], [[3ggj]], [[4jit]], [[4jls]] - hHPRT + guanine derivative<br />
**[[3gep]], [[3ggj]], [[4jit]], [[4jls]] - hHPRT + guanine derivative<br />
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**[[4ijq]], [[4rab]], [[4rac]], [[4rad]], [[4ran]], [[4rao]], [[4raq]] - hHPRT + inhibitor<br />
**[[4ijq]], [[4rab]], [[4rac]], [[4rad]], [[4ran]], [[4rao]], [[4raq]] - hHPRT + inhibitor<br />
**[[4kn6]] - hHPRT + antiviral agent<br />
**[[4kn6]] - hHPRT + antiviral agent<br />
 +
**[[1a98]], [[1a97]] - EcHPRT (mutant) + GMP<br />
 +
**[[1g9s]] - EcHPRT + IMP<BR />
 +
**[[1g9t]] - EcHPRT + GMP<br />
**[[1hgx]] - HPRT + GMP – ''Tritrichomonas foetus''<br />
**[[1hgx]] - HPRT + GMP – ''Tritrichomonas foetus''<br />
**[[1qk3]] - TgHPRT + GMP<br />
**[[1qk3]] - TgHPRT + GMP<br />
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*Hypoxanthine-guanine phosphoribosyltransferase ternary complex
*Hypoxanthine-guanine phosphoribosyltransferase ternary complex
 +
**[[1bzy]] - hHPRT + inhibitor + guanine derivative<br />
**[[1a95]] - EcHPRT + guanine + PRPP derivative<br />
**[[1a95]] - EcHPRT + guanine + PRPP derivative<br />
**[[1a96]] - EcHPRT + xanthine + PRPP derivative<br />
**[[1a96]] - EcHPRT + xanthine + PRPP derivative<br />
-
**[[1bzy]] - hHPRT + inhibitor + guanine derivative<br />
 
**[[1tc2]], [[1i0i]], [[1i0l]], [[1i13]], [[1i14]] – TcHPRT + pyrimidine derivative + PRPP derivative<br />
**[[1tc2]], [[1i0i]], [[1i0l]], [[1i13]], [[1i14]] – TcHPRT + pyrimidine derivative + PRPP derivative<br />
**[[1p18]] - TcHPRT (mutant) + pyrimidine derivative + PRPP<BR />
**[[1p18]] - TcHPRT (mutant) + pyrimidine derivative + PRPP<BR />
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*'''Quinolinic acid phosphoribosyltransferase'''
*'''Quinolinic acid phosphoribosyltransferase'''
-
**[[1o4u]] - TmQAPRT – ''Thermotoga maritima''<br />
 
**[[2jbm]], [[5ayx]], [[4kwv]] – hQAPRT<br />
**[[2jbm]], [[5ayx]], [[4kwv]] – hQAPRT<br />
**[[3c2e]] - yQAPRT <br />
**[[3c2e]] - yQAPRT <br />
 +
**[[1o4u]] - TmQAPRT – ''Thermotoga maritima''<br />
**[[1qpo]] – MtQAPRT – ''Mycobacterium tuberculosis'' <br />
**[[1qpo]] – MtQAPRT – ''Mycobacterium tuberculosis'' <br />
*Quinolinic acid phosphoribosyltransferase complex
*Quinolinic acid phosphoribosyltransferase complex
-
**[[1qap]] - StQAPRT + quinolinic acid<br />
 
-
**[[1qpr]] - MtQAPRT + PRPP derivative <br />
 
-
**[[1qpn]] – MtQAPRT + nicotinate mononucleotide <br />
 
-
**[[1qpq]] - MtQAPRT + quinolinic acid<br />
 
**[[5ayy]] - hQAPRT + quinolinic acid<br />
**[[5ayy]] - hQAPRT + quinolinic acid<br />
 +
**[[4kww]] – hQAPRT + phthalate <br />
 +
**[[5ayz]] – hQAPRT + nicotinate mononucleotide <br />
 +
**[[4i9a]] – QAPRT + nicotinate mononucleotide – pig<br />
**[[3c2o]] - yQAPRT + quinolinic acid<br />
**[[3c2o]] - yQAPRT + quinolinic acid<br />
**[[3c2f]] - yQAPRT + PRPP<BR />
**[[3c2f]] - yQAPRT + PRPP<BR />
**[[3c2r]] - yQAPRT + inhibitor<br />
**[[3c2r]] - yQAPRT + inhibitor<br />
**[[3c2v]] - yQAPRT + inhibitor + PRPP<BR />
**[[3c2v]] - yQAPRT + inhibitor + PRPP<BR />
-
**[[4i9a]] – QAPRT + nicotinate mononucleotide – pig<br />
+
**[[1qap]] - StQAPRT + quinolinic acid<br />
 +
**[[1qpr]] - MtQAPRT + PRPP derivative <br />
 +
**[[1qpn]] – MtQAPRT + nicotinate mononucleotide <br />
 +
**[[1qpq]] - MtQAPRT + quinolinic acid<br />
**[[2b7n]] – HpQAPRT + quinolinic acid <br />
**[[2b7n]] – HpQAPRT + quinolinic acid <br />
-
**[[4kww]] – hQAPRT + phthalate <br />
 
**[[2b7p]] – HpQAPRT + phthalate <br />
**[[2b7p]] – HpQAPRT + phthalate <br />
**[[2b7q]] – HpQAPRT + nicotinate mononucleotide <br />
**[[2b7q]] – HpQAPRT + nicotinate mononucleotide <br />
-
**[[5ayz]] – hQAPRT + nicotinate mononucleotide <br />
 
*'''Uracil phosphoribosyltransferase'''
*'''Uracil phosphoribosyltransferase'''
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**[[1upu]] - TgUPRT (mutant) + UMP<br />
**[[1upu]] - TgUPRT (mutant) + UMP<br />
-
**[[1o5o]] - TmUPRT + UMP<br />
 
**[[1jlr]] - TgUPRT (mutant) + GTP<br />
**[[1jlr]] - TgUPRT (mutant) + GTP<br />
**[[1bd4]] - TgUPRT (mutant) + uracil<br />
**[[1bd4]] - TgUPRT (mutant) + uracil<br />
**[[1upf]] - TgUPRT (mutant) + fluorouracil<br />
**[[1upf]] - TgUPRT (mutant) + fluorouracil<br />
-
**[[1i5e]], [[2igb]] - UPRT + UMP – ''Bacillus caldolyticus''<br />
 
**[[1jls]] - TgUPRT (mutant) + uracil + PRPP<BR />
**[[1jls]] - TgUPRT (mutant) + uracil + PRPP<BR />
 +
**[[1i5e]], [[2igb]] - UPRT + UMP – ''Bacillus caldolyticus''<br />
 +
**[[1o5o]] - TmUPRT + UMP<br />
**[[1vst]], [[3g6w]] - SsUPRT + GTP + PRPP
**[[1vst]], [[3g6w]] - SsUPRT + GTP + PRPP
*'''Adenine phosphoribosyltransferase'''
*'''Adenine phosphoribosyltransferase'''
-
**[[1qcc]], [[1qcd]] - LdAPRT – ''Leishmania donovani''<br />
 
**[[1g2p]], [[1g2q]] – yAPRT <br />
**[[1g2p]], [[1g2q]] – yAPRT <br />
 +
**[[1qcc]], [[1qcd]] - LdAPRT – ''Leishmania donovani''<br />
**[[2dy0]] - EcAPRT <br />
**[[2dy0]] - EcAPRT <br />
**[[4lza]] – APRT – ''Thermoanaerobacter pseudethanolicus''<br />
**[[4lza]] – APRT – ''Thermoanaerobacter pseudethanolicus''<br />
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*Adenine phosphoribosyltransferase complex
*Adenine phosphoribosyltransferase complex
 +
**[[1ore]], [[1zn8]], [[1zn9]] - hAPRT + AMP<br />
 +
**[[4x44]], [[4x45]] - hAPRT (mutant) + AMP <br />
 +
**[[1zn7]] - hHGPRT + adenine + PRPP<BR />
**[[1qb7]] - LdAPRT + adenine<br />
**[[1qb7]] - LdAPRT + adenine<br />
 +
**[[1qb8]] - LdAPRT + AMP<br />
**[[4trc]] - SsAPRT + adenine<br />
**[[4trc]] - SsAPRT + adenine<br />
**[[4ts5]] - SsAPRT + AMP<br />
**[[4ts5]] - SsAPRT + AMP<br />
-
**[[1qb8]] - LdAPRT + AMP<br />
 
-
**[[1ore]], [[1zn8]], [[1zn9]] - hAPRT + AMP<br />
 
-
**[[4x44]], [[4x45]] - hAPRT (mutant) + AMP - human<br />
 
**[[5b6h]] - YpAPRT + AMP <br />
**[[5b6h]] - YpAPRT + AMP <br />
**[[1mzv]] - LtAPRT + AMP<br />
**[[1mzv]] - LtAPRT + AMP<br />
**[[4ts7]] - SsAPRT + ADP<br />
**[[4ts7]] - SsAPRT + ADP<br />
-
**[[1zn7]] - hHGPRT + adenine + PRPP<BR />
 
**[[1l1q]] - GiAPRT + adenine derivative<br />
**[[1l1q]] - GiAPRT + adenine derivative<br />
**[[1l1r]] - GiAPRT + adenine derivative + PRPP<BR />
**[[1l1r]] - GiAPRT + adenine derivative + PRPP<BR />
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*'''Nicotinate phosphoribosyltransferase'''
*'''Nicotinate phosphoribosyltransferase'''
 +
**[[4yub]] - hNIPRT <br />
**[[1vlp]] - yNIPRT <br />
**[[1vlp]] - yNIPRT <br />
**[[1ybe]] - NIPRT – ''Agrobacterium tumefaciens''<br />
**[[1ybe]] - NIPRT – ''Agrobacterium tumefaciens''<br />
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**[[3os4]] - NIPRT – ''Yersinia pestis''<br />
**[[3os4]] - NIPRT – ''Yersinia pestis''<br />
**[[4hl7]] - VcNIPRT <br />
**[[4hl7]] - VcNIPRT <br />
-
**[[4yub]] - hNIPRT <br />
 
*Nicotinate phosphoribosyltransferase complex
*Nicotinate phosphoribosyltransferase complex
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**[[1yte]] - TaNIPRT + PRPP<BR />
**[[1yte]] - TaNIPRT + PRPP<BR />
**[[1ytk]] - TaNIPRT + NAMN<br />
**[[1ytk]] - TaNIPRT + NAMN<br />
-
**[[4mzy]] – NIPRT + malonate + Pi<br />
+
**[[4mzy]] – NIPRT + malonate + Pi – ''Enterococcus faecalis''<br />
*'''Nicotinamide phosphoribosyltransferase'''
*'''Nicotinamide phosphoribosyltransferase'''
 +
**[[2e5b]] – hNMPRT<br />
**[[2gvl]] - mNMPRT – mouse<br />
**[[2gvl]] - mNMPRT – mouse<br />
-
**[[2g95]] - NMPRT - rat<br />
 
**[[2h3b]] – mNMPRT (mutant) <br />
**[[2h3b]] – mNMPRT (mutant) <br />
-
**[[2e5b]] – hNMPRT
+
**[[2g95]] - NMPRT - rat<br />
*Nicotinamide phosphoribosyltransferase complex
*Nicotinamide phosphoribosyltransferase complex
-
**[[2h3d]] - mNMPRT + NMN<BR />
 
**[[2gvg]] - hNMPRT + NMN<BR />
**[[2gvg]] - hNMPRT + NMN<BR />
-
**[[2g96]] - rNMPRT + NMN<BR />
 
**[[2g97]], [[3g8e]] - rNMPRT + FK-866<br />
**[[2g97]], [[3g8e]] - rNMPRT + FK-866<br />
**[[2gvj]] - hNMPRT + FK-866<br />
**[[2gvj]] - hNMPRT + FK-866<br />
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**[[3dhd]], [[3dhf]] - hNMPRT + pyrophosphate + NMN<BR />
**[[3dhd]], [[3dhf]] - hNMPRT + pyrophosphate + NMN<BR />
**[[3dkj]], [[3dkl]] - hNMPRT + benzamide + PRPP<BR />
**[[3dkj]], [[3dkl]] - hNMPRT + benzamide + PRPP<BR />
 +
**[[2h3d]] - mNMPRT + NMN<BR />
 +
**[[2g96]] - rNMPRT + NMN<BR />
 +
**[[2g97]], [[3g8e]] - rNMPRT + FK-866<br />
 +
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:25, 19 November 2019

Yeast orotate phosphoribosyltransferase dimer complex with orotate and PRPP (PDB entry 2ps1)

Drag the structure with the mouse to rotate

3D structures of phosphoribosyltransferase

Updated on 19-November-2019

References

  1. ↑ Sculley DG, Dawson PA, Emmerson BT, Gordon RB. A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. Hum Genet. 1992 Nov;90(3):195-207. PMID:1487231
  2. ↑ 2.0 2.1 Gonzalez-Segura L, Witte JF, McClard RW, Hurley TD. Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase. Biochemistry. 2007 Dec 11;46(49):14075-86. Epub 2007 Nov 20. PMID:18020427 doi:10.1021/bi701023z
  3. ↑ Foster AC, Whetsell WO Jr, Bird ED, Schwarcz R. Quinolinic acid phosphoribosyltransferase in human and rat brain: activity in Huntington's disease and in quinolinate-lesioned rat striatum. Brain Res. 1985 Jun 17;336(2):207-14. PMID:3159462
  4. ↑ Carter D, Donald RG, Roos D, Ullman B. Expression, purification, and characterization of uracil phosphoribosyltransferase from Toxoplasma gondii. Mol Biochem Parasitol. 1997 Aug;87(2):137-44. PMID:9247925
  5. ↑ . PMID:121011881
  6. ↑ Castell A, Short FL, Evans GL, Cookson TV, Bulloch EM, Joseph DD, Lee CE, Parker EJ, Baker EN, Lott JS. Substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition. Biochemistry. 2013 Jan 30. PMID:23363292 doi:http://dx.doi.org/10.1021/bi301387m
  7. ↑ Pedreno S, Pisco JP, Larrouy-Maumus G, Kelly G, de Carvalho LP. Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase. Biochemistry. 2012 Oct 9;51(40):8027-38. doi: 10.1021/bi300808b. Epub 2012 Sep, 27. PMID:22989207 doi:http://dx.doi.org/10.1021/bi300808b
  8. ↑ Galassi L, Di Stefano M, Brunetti L, Orsomando G, Amici A, Ruggieri S, Magni G. Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis. Biochimie. 2012 Feb;94(2):300-9. doi: 10.1016/j.biochi.2011.06.033. Epub 2011 Jul, 3. PMID:21742010 doi:http://dx.doi.org/10.1016/j.biochi.2011.06.033
  9. ↑ Imai S. Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases. Curr Pharm Des. 2009;15(1):20-8. PMID:19149599
  10. ↑ Tohyama J, Nanba E, Ohno K. Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency: identification of point mutations in Japanese patients with Lesch-Nyhan syndrome and hereditary gout and their permanent expression in an HPRT-deficient mouse cell line. Hum Genet. 1994 Feb;93(2):175-81. PMID:8112742
  11. ↑ Montecucco F, Cea M, Cagnetta A, Damonte P, Nahimana A, Ballestrero A, Del Rio A, Bruzzone S, Nencioni A. Nicotinamide phosphoribosyltransferase as a target in inflammation- related disorders. Curr Top Med Chem. 2013;13(23):2930-8. PMID:24171767

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