Sandbox Reserved 1580
From Proteopedia
(Difference between revisions)
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<StructureSection load='1NYL' size='340' side='right' caption='Glutaminyl-tRNA synthetase' scene=''> | <StructureSection load='1NYL' size='340' side='right' caption='Glutaminyl-tRNA synthetase' scene=''> | ||
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| - | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID: | + | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:12737824</ref> to the rescue. |
== Overview == | == Overview == | ||
| - | Glutaminyl-tRNA synthetase or GlnRS is a class 1 tRNA synthetase that requires tRNA binding for adenylate synthesis, which suggests that the large substrate could be required to form the active site structure. | + | Glutaminyl-tRNA synthetase or GlnRS is a class 1 tRNA synthetase that requires tRNA binding for adenylate synthesis, which suggests that the large substrate could be required to form the active site structure. (Citation 1) |
== Structure == | == Structure == | ||
| - | The crystal structure of ligand-free E. coli glutaminyl-tRNA synthetase at 2.4 A shows substrate binding is needed to construct a catalytically proficient active site. | + | The crystal structure of ligand-free E. coli glutaminyl-tRNA synthetase at 2.4 A shows substrate binding is needed to construct a catalytically proficient active site. (citation 1) |
== Disease == | == Disease == | ||
| - | + | Mutations in the Glutaminyl-tRNA synthetase gene have been linked to cause epileptic encephalopathy. (Citation 2) | |
== Structural highlights == | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
| - | < | + | <Reference/> |
Revision as of 17:39, 19 November 2019
| This Sandbox is Reserved from September 14, 2021, through May 31, 2022, for use in the class Introduction to Biochemistry taught by User:John Means at the University of Rio Grande, Rio Grande, OH, USA. This reservation includes 5 reserved sandboxes (Sandbox Reserved 1590 through Sandbox Reserved 1594). |
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Glutaminyl-tRNA Synthetase
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References
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