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From Proteopedia
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Glutaminyl-tRNA synthetase or GlnRS is a class 1 tRNA synthetase that requires tRNA binding for adenylate synthesis, which suggests that the large substrate could be required to form the active site structure. 12737824 (Citation 1) | Glutaminyl-tRNA synthetase or GlnRS is a class 1 tRNA synthetase that requires tRNA binding for adenylate synthesis, which suggests that the large substrate could be required to form the active site structure. 12737824 (Citation 1) | ||
== Structure == | == Structure == | ||
| - | The crystal structure of ligand-free E. coli glutaminyl-tRNA synthetase at 2.4 A shows substrate binding is needed to construct a catalytically proficient active site. 12737824 (citation 1) The backbone atoms of 94 amino acid residues, 25–31, 36–63, 77–99, 213–239, and 252–260 could be superimposed on their counterparts showing similarities close to each other. 12737824 (Citation 1) | + | The crystal structure of ligand-free E. coli glutaminyl-tRNA synthetase at 2.4 A shows substrate binding is needed to construct a catalytically proficient active site. 12737824 (citation 1) The backbone atoms of 94 amino acid residues, <scene name='82/824625/Backbone_atoms_amino_acid_comp/1'>25–31, 36–63, 77–99, 213–239, and 252–260</scene> could be superimposed on their counterparts showing similarities close to each other. 12737824 (Citation 1) |
| - | == | + | == Mutations == |
Mutations in the coding of glutaminyl-tRNA synthetase can cause seizures and problems in the cerebral cortex. 24656866 (Citation 2) | Mutations in the coding of glutaminyl-tRNA synthetase can cause seizures and problems in the cerebral cortex. 24656866 (Citation 2) | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 00:23, 20 November 2019
| This Sandbox is Reserved from September 14, 2021, through May 31, 2022, for use in the class Introduction to Biochemistry taught by User:John Means at the University of Rio Grande, Rio Grande, OH, USA. This reservation includes 5 reserved sandboxes (Sandbox Reserved 1590 through Sandbox Reserved 1594). |
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Glutaminyl-tRNA Synthetase
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