Sandbox GGC12
From Proteopedia
(Difference between revisions)
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== Structure == | == Structure == | ||
| - | The structure of the TBP has a pseudo-symmetry within its structure which contains two 88- amino acid repeats. This structure attaches to a DNA structure of deformity in the helix; the deformity is for the purpose of binding. The DNA structure's minor groove is open- wide to have complete access for the TBP to bind within it. | + | The structure of the TBP has a pseudo-symmetry within its structure which contains two 88- amino acid repeats. This structure attaches to a DNA structure of deformity in the helix; the deformity is for the purpose of binding. The DNA structure's minor groove is open- wide to have complete access for the TBP to bind within it (2). |
== Function == | == Function == | ||
| - | The TATA-Binding protein, TBP, is a factor in the process of Transcription within Eukaryotes. This binding protein is a subunit in the family of TFIID. The function of the TBP is to bind to a DNA sequence which is the TATA box. This allows RNA Polymerase II to bind to the promoter. This is the beginning of the process of Transcription. | + | The TATA-Binding protein, TBP, is a factor in the process of Transcription within Eukaryotes. This binding protein is a subunit in the family of TFIID. The function of the TBP is to bind to a DNA sequence which is the TATA box. This allows RNA Polymerase II to bind to the promoter. This is the beginning of the process of Transcription (1). |
== Relevance == | == Relevance == | ||
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-The first ever for the TBP was found in fruit flies, specifically Drosophila flies. | -The first ever for the TBP was found in fruit flies, specifically Drosophila flies. | ||
| - | -This is not the same idea in prokaryotes. Prokaryotes have a different concept because it is a Pribnow box instead of a TATA box. | + | -This is not the same idea in prokaryotes. Prokaryotes have a different concept because it is a Pribnow box instead of a TATA box (2). |
| - | -Another name for the TATA box is the Goldberg- Hogness box. | + | -Another name for the TATA box is the Goldberg- Hogness box (1). |
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== References == | == References == | ||
<references/> | <references/> | ||
| - | Kim, J., & Iyer, V. R. (2004). Global role of TATA box-binding protein recruitment to promoters in mediating gene expression profiles. Molecular and cellular biology, 24(18), 8104–8112. doi:10.1128/MCB.24.18.8104-8112.2004 | + | 1. Kim, J., & Iyer, V. R. (2004). Global role of TATA box-binding protein recruitment to promoters in mediating gene expression profiles. Molecular and cellular biology, 24(18), 8104–8112. doi:10.1128/MCB.24.18.8104-8112.2004 |
| - | Juo, Zong Sean, et al. “How Proteins Recognize the TATA Box.” Journal of Molecular Biology, vol. 261, no. 2, 1996, pp. 239–254., doi:10.1006/jmbi.1996.0456. | + | 2. Juo, Zong Sean, et al. “How Proteins Recognize the TATA Box.” Journal of Molecular Biology, vol. 261, no. 2, 1996, pp. 239–254., doi:10.1006/jmbi.1996.0456. |
Revision as of 13:35, 20 November 2019
TATA-Binding Protein (TBP)
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References
1. Kim, J., & Iyer, V. R. (2004). Global role of TATA box-binding protein recruitment to promoters in mediating gene expression profiles. Molecular and cellular biology, 24(18), 8104–8112. doi:10.1128/MCB.24.18.8104-8112.2004
2. Juo, Zong Sean, et al. “How Proteins Recognize the TATA Box.” Journal of Molecular Biology, vol. 261, no. 2, 1996, pp. 239–254., doi:10.1006/jmbi.1996.0456.
