6mqk
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of GTPase Domain of Human Septin 12 in complex with GDP== | |
| - | + | <StructureSection load='6mqk' size='340' side='right'caption='[[6mqk]], [[Resolution|resolution]] 2.19Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6mqk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MQK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqk OCA], [http://pdbe.org/6mqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqk RCSB], [http://www.ebi.ac.uk/pdbsum/6mqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqk ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Brandao-Neto, J]] | [[Category: Brandao-Neto, J]] | ||
| - | [[Category: | + | [[Category: Castro, D K.S V]] |
| - | [[Category: | + | [[Category: Garratt, R C]] |
| - | [[Category: | + | [[Category: Pereira, H M]] |
| - | [[Category: Ulian, A | + | [[Category: Ulian, A P.U]] |
| + | [[Category: Cytoskeleton component septin gtpase spermatogenesis]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 15:24, 20 November 2019
Crystal Structure of GTPase Domain of Human Septin 12 in complex with GDP
| |||||||||||
