5uaz
From Proteopedia
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==Crystal structure of the yeast nucleoporin== | ==Crystal structure of the yeast nucleoporin== | ||
| - | <StructureSection load='5uaz' size='340' side='right' caption='[[5uaz]], [[Resolution|resolution]] 1.75Å' scene=''> | + | <StructureSection load='5uaz' size='340' side='right'caption='[[5uaz]], [[Resolution|resolution]] 1.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5uaz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UAZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5uaz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UAZ FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUP53, YMR153W, YM8520.02 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uaz OCA], [http://pdbe.org/5uaz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uaz RCSB], [http://www.ebi.ac.uk/pdbsum/5uaz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uaz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uaz OCA], [http://pdbe.org/5uaz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uaz RCSB], [http://www.ebi.ac.uk/pdbsum/5uaz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uaz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/NUP53_YEAST NUP53_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP53 may play an important role in cell cycle regulation by inhibiting PSE1 transport functions during mitosis and sequestration of MAD1-MAD2 in a cell cycle-dependent manner. It also seems to play an important role in de novo NPC assembly by associating with nuclear membranes and driving their proliferation.<ref>PMID:9864357</ref> <ref>PMID:11352933</ref> <ref>PMID:12403813</ref> <ref>PMID:12473689</ref> <ref>PMID:14697200</ref> <ref>PMID:12604785</ref> | [[http://www.uniprot.org/uniprot/NUP53_YEAST NUP53_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP53 may play an important role in cell cycle regulation by inhibiting PSE1 transport functions during mitosis and sequestration of MAD1-MAD2 in a cell cycle-dependent manner. It also seems to play an important role in de novo NPC assembly by associating with nuclear membranes and driving their proliferation.<ref>PMID:9864357</ref> <ref>PMID:11352933</ref> <ref>PMID:12403813</ref> <ref>PMID:12473689</ref> <ref>PMID:14697200</ref> <ref>PMID:12604785</ref> | ||
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| + | ==See Also== | ||
| + | *[[Nucleoporin 3D structures|Nucleoporin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Baker's yeast]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Blobel, G]] | [[Category: Blobel, G]] | ||
[[Category: Blus, B J]] | [[Category: Blus, B J]] | ||
Revision as of 16:43, 20 November 2019
Crystal structure of the yeast nucleoporin
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