159d

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[[Image:159d.gif|left|200px]]
[[Image:159d.gif|left|200px]]
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{{Structure
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|PDB= 159d |SIZE=350|CAPTION= <scene name='initialview01'>159d</scene>, resolution 1.800&Aring;
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The line below this paragraph, containing "STRUCTURE_159d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DI:2&#39;-DEOXYINOSINE-5&#39;-MONOPHOSPHATE'>DI</scene>, <scene name='pdbligand=DMY:DISTAMYCIN+A'>DMY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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|DOMAIN=
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{{STRUCTURE_159d| PDB=159d | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=159d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=159d OCA], [http://www.ebi.ac.uk/pdbsum/159d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=159d RCSB]</span>
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}}
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'''SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX'''
'''SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX'''
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==About this Structure==
==About this Structure==
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159D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=159D OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=159D OCA].
==Reference==
==Reference==
Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex., Chen X, Ramakrishnan B, Rao ST, Sundaralingam M, Nat Struct Biol. 1994 Mar;1(3):169-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7656035 7656035]
Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex., Chen X, Ramakrishnan B, Rao ST, Sundaralingam M, Nat Struct Biol. 1994 Mar;1(3):169-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7656035 7656035]
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[[Category: Protein complex]]
 
[[Category: Chen, X.]]
[[Category: Chen, X.]]
[[Category: Ramakrishnan, B.]]
[[Category: Ramakrishnan, B.]]
[[Category: Rao, S T.]]
[[Category: Rao, S T.]]
[[Category: Sundaralingam, M.]]
[[Category: Sundaralingam, M.]]
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[[Category: b-dna]]
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[[Category: B-dna]]
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[[Category: complexed with drug]]
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[[Category: Complexed with drug]]
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[[Category: double helix]]
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[[Category: Double helix]]
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[[Category: modified]]
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[[Category: Modified]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:31:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:28:35 2008''
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Revision as of 06:31, 2 May 2008

Image:159d.gif

Template:STRUCTURE 159d

SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX


Overview

Here we report the 1.8A X-ray structure of a 2:1 drug-DNA complex between distamycin A and an alternating B-DNA octamer duplex d(ICICICIC)2. The two distamycin A molecules are bound side by side with dyad symmetry in an antiparallel orientation in the expanded minor groove. The amides of each drug molecule are hydrogen bonded to the minor groove base atoms of only one DNA strand. The complex not only shows binding of two drug molecules, but the DNA duplex also exhibits striking low-high alternations in the helical twist angles, the sugar puckering and the phosphate conformations, providing the basis for a new model for an alternating B-DNA with a dinucleotide repeat.

About this Structure

Full crystallographic information is available from OCA.

Reference

Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex., Chen X, Ramakrishnan B, Rao ST, Sundaralingam M, Nat Struct Biol. 1994 Mar;1(3):169-75. PMID:7656035 Page seeded by OCA on Fri May 2 09:31:36 2008

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