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1mm0

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Revision as of 18:38, 20 November 2019

Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger

Structural highlights

1mm0 is a 1 chain structure with sequence from Pseus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TERN_PSEUS] Weak activity against Gram-positive bacteria B.megaterium, S.pyogenes and M.luteus, strong activity against yeasts C.albicans, C.neoformans and S.cerevisiae and filamentous fungi F.oxysporum, F.culmorum, N.crassa and N.hematococca. Less active against filamentous fungus T.viride. Inactive against Gram-positive bacteria A.viridans and S.aureus, filamentous fungi A.fumigatus and B.bassiana and yeast C.glabrata.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The solution structure of termicin from hemocytes of the termite Pseudacanthotermes spiniger was determined by proton two-dimensional nuclear magnetic resonance spectroscopy and molecular modeling techniques. Termicin is a cysteine-rich antifungal peptide also exhibiting a weak antibacterial activity. The global fold of termicin consists of an alpha-helical segment (Phe4-Gln14) and a two-stranded (Phe19-Asp25 and Gln28-Phe33) antiparallel beta-sheet forming a "cysteine stabilized alphabeta motif" (CSalphabeta) also found in antibacterial and antifungal defensins from insects and from plants. Interestingly, termicin shares more structural similarities with the antibacterial insect defensins and with MGD-1, a mussel defensin, than with the insect antifungal defensins such as drosomycin and heliomicin. These structural comparisons suggest that global fold alone does not explain the difference between antifungals and antibacterials. The antifungal properties of termicin may be related to its marked hydrophobicity and its amphipatic structure as compared to the antibacterial defensins. [SWISS-PROT accession number: Termicin (P82321); PDB accession number: 1MM0.]

Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger.,Da Silva P, Jouvensal L, Lamberty M, Bulet P, Caille A, Vovelle F Protein Sci. 2003 Mar;12(3):438-46. PMID:12592014^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Da Silva P, Jouvensal L, Lamberty M, Bulet P, Caille A, Vovelle F. Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger. Protein Sci. 2003 Mar;12(3):438-46. PMID:12592014

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mm0"

@@ Line 1: / Line 1: @@
 ==Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger==
-<StructureSection load='1mm0' size='340' side='right' caption='[[1mm0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='1mm0' size='340' side='right'caption='[[1mm0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1mm0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseus Pseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MM0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MM0 FirstGlance]. <br>
@@ Line 31: / Line 31: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Pseus]]
 [[Category: Bulet, P]]

1mm0

From Proteopedia

Revision as of 18:38, 20 November 2019

Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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