Phosphoribosyltransferase

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**[[4qri]] – HPRT – ''Leptospira interrogans''<br />
**[[4qri]] – HPRT – ''Leptospira interrogans''<br />
**[[4rqa]], [[4rqb]] – HPRT – ''Staphylococcus aureus''<br />
**[[4rqa]], [[4rqb]] – HPRT – ''Staphylococcus aureus''<br />
 +
**[[5xtk]], [[6kp5]] – YpeHGPRT – ''Yersinia pestis''<br />
 +
**[[6kqc]] - YpeHGPRT (mutant) <br />
 +
**[[5esw]] - LpHGPRT – ''Legionella pneumophila''<BR />
 +
**[[6igs]] - FtHGPRT <br />
 +
**[[6d9q]] - BaHGPRT<br />
*Hypoxanthine-guanine phosphoribosyltransferase binary complex with nucleotide
*Hypoxanthine-guanine phosphoribosyltransferase binary complex with nucleotide
 +
**[[1hmp]] - hHGPRT + GMP - human<br />
 +
**[[3gep]], [[3ggj]], [[4jit]], [[4jls]] - hHGPRT + guanine derivative<br />
 +
**[[2jky]], [[2jkz]], [[2xbu]] - yHGPRT + GMP<br />
 +
**[[1a98]], [[1a97]] - EcHGPRT (mutant) + GMP<br />
 +
**[[1g9s]] - EcHGPRT + IMP<BR />
 +
**[[1g9t]] - EcHGPRT + GMP<br />
 +
**[[5knx]], [[5knv]], [[5knu]], [[5knt]], [[5kns]], [[5knr]] - EcHGPRT + nucleoside phosphonate<br />
 +
**[[1hgx]] - HGPRT + GMP – ''Tritrichomonas foetus''<br />
 +
**[[1qk3]] - TgHGPRT + GMP<br />
 +
**[[1qk4]] - TgHGPRT + IMP<BR />
 +
**[[1p19]] - TcHGPRT + IMP<BR />
 +
**[[1p17]] - TcHGPRT (mutant) + IMP<BR />
 +
**[[1yfz]] - TteHGPRT + IMP<BR />
 +
**[[1pzm]] - LtHGPRT + GMP – ''Leishmania tarentolae''<br />
 +
**[[1y0b]] - BsHGPRT + GTP – ''Bacillus subtilis''<br />
 +
**[[2fxv]] - BsHGPRT + GMP<br />
 +
**[[3kb8]] - BaHGPRT + GMP<br />
 +
**[[6d9s]] - BaHGPRT + PPGPP<br />
 +
**[[3acc]] - TtHGPRT + GMP<br />
 +
**[[3acd]] - TtHGPRT + IMP<BR />
 +
**[[1d6n]] - LdAPRT + AMP derivative<br />
 +
**[[4zfn]] - SsHGPRT + GMP<br />
 +
**[[5kam]] - TbHGPRT + IMP - Trypanosoma brucei <BR />
 +
**[[5jv5]], [[6mxc]] - TbHGPRT + GMP<BR />
 +
**[[6mxb]], [[6mxg]] - TbHGPRT + XMP<BR />
 +
**[[6mxd]] - TbHGPRT + IMP<BR />
 +
**[[5ipf]] - HGPRT + IMP – Schistosoma mansoni<BR />
 +
**[[5esx]] - LpHGPRT + GMP <BR />
-
**[[1hmp]], [[2vfa]] - hHPRT + GMP<br />
+
==Hypoxanthine-guanine PRT binary complex ==
-
**[[3gep]], [[3ggj]], [[4jit]], [[4jls]] - hHPRT + guanine derivative<br />
+
 
-
**[[3ggc]] - hHPRT + hypoxanthine derivative<br />
+
**[[3ggc]] - hHGPRT + hypoxanthine derivative<br />
-
**[[4ijq]], [[4rab]], [[4rac]], [[4rad]], [[4ran]], [[4rao]], [[4raq]] - hHPRT + inhibitor<br />
+
**[[4ijq]], [[4rab]], [[4rac]], [[4rad]], [[4ran]], [[4rao]], [[4raq]], [[6bnj]], **[[5w8v]], [[5hia]] - hHGPRT + inhibitor<br />
-
**[[4kn6]] - hHPRT + antiviral agent<br />
+
**[[5bsk]], [[5brn]] - hHGPRT (mutant) + nucleoside phosphonate <br />
-
**[[1a98]], [[1a97]] - EcHPRT (mutant) + GMP<br />
+
**[[4kn6]] - hHGPRT + antiviral agent<br />
-
**[[1g9s]] - EcHPRT + IMP<BR />
+
**[[1dqp]] - GiHGPRT + imucillin – ''Giardia intestinalis''<br />
-
**[[1g9t]] - EcHPRT + GMP<br />
+
**[[3ozf]] - PfHGPRT + hypoxanthine<br />
-
**[[1hgx]] - HPRT + GMP – ''Tritrichomonas foetus''<br />
+
**[[3ozg]] - PfHGPRT + inhibitor<br />
-
**[[1qk3]] - TgHPRT + GMP<br />
+
**[[5kny]] - MtHGPRT + inhibitor<br />
-
**[[1qk4]] - TgHPRT + IMP<BR />
+
**[[4rhx]], [[4rhu]], [[4rht]] - MtHGPRT + nucleoside phosphonate <br />
-
**[[1p19]] - TcHPRT + IMP<BR />
+
**[[1dqn]] - GiHGPRT + transition state analog<br />
-
**[[1p17]] - TcHPRT (mutant) + IMP<BR />
+
**[[4z1o]] - SsHGPRT + PRPP - Sulfolobus solfataricus<br />
-
**[[1yfz]] - TteHPRT + IMP<BR />
+
**[[6bo7]] - HGPRT + inhibitor – Plasmodium vivax<br />
-
**[[1dqp]] - GiHPRT + imucillin – ''Giardia intestinalis''<br />
+
**[[6aqo]], [[6ar9]], [[6apv]], [[6apu]], [[6apt]], [[6aps]], [[5kap]], [[5k51]], [[5jsq]] - TbHGPRT + inhibitor <br />
-
**[[1pzm]] - LtHPRT + GMP – ''Leishmania tarentolae''<br />
+
-
**[[1y0b]] - BsHPRT + GTP – ''Bacillus subtilis''<br />
+
-
**[[2fxv]] - BsHPRT + GMP<br />
+
-
**[[3kb8]] - BaHPRT + GMP<br />
+
-
**[[2jky]], [[2jkz]], [[2xbu]] - yHPRT + GMP<br />
+
-
**[[3acc]] - TtHPRT + GMP<br />
+
-
**[[3acd]] - TtHPRT + IMP<BR />
+
-
**[[1cjb]] - PfHPRT + pyrophosphate <br />
+
-
**[[3ozf]] - PfHPRT + hypoxanthine<br />
+
-
**[[3ozg]] - PfHPRT + inhibitor<br />
+
-
**[[1dqn]] - GiHPRT + transition state analog<br />
+
-
**[[1d6n]] - LdHPRT + AMP derivative<br />
+
-
**[[4z1o]] - SsHPRT + PRPP - ''Sulfolobus solfataricus''<br />
+
-
**[[4zfn]] - SsHPRT + GMP<br />
+
*Hypoxanthine-guanine phosphoribosyltransferase ternary complex
*Hypoxanthine-guanine phosphoribosyltransferase ternary complex
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**[[1fsg]] - TgHPRT + guanine derivative + PRPP<BR />
**[[1fsg]] - TgHPRT + guanine derivative + PRPP<BR />
**[[1cjb]] - PfHPRT + pyrophosphate + inhibitor<br />
**[[1cjb]] - PfHPRT + pyrophosphate + inhibitor<br />
 +
**[[5knq]], [[5knp]] - MtHGPRT + pyrophosphate + nucleoside phosphonate <br />
 +
**[[4rhy]] - MtHGPRT + pyrophosphate + GMP<br />
 +
**[[6d9r]] - BaHGPRT + PRPP + deazaquanine<br />
 +
 +
*'''Hypoxanthine-guanine-xanthine PRT or purine PRT'''
 +
 +
**[[5bqo]] - SsHGXPRT <br />
 +
**[[5bqp]] - SsHGXPRT + pyrophosphate <br />
*'''Quinolinic acid phosphoribosyltransferase'''
*'''Quinolinic acid phosphoribosyltransferase'''
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**[[1o4u]] - TmQAPRT – ''Thermotoga maritima''<br />
**[[1o4u]] - TmQAPRT – ''Thermotoga maritima''<br />
**[[1qpo]] – MtQAPRT – ''Mycobacterium tuberculosis'' <br />
**[[1qpo]] – MtQAPRT – ''Mycobacterium tuberculosis'' <br />
 +
**[[5hul]] - SpQAPRT (mutant)<br />
*Quinolinic acid phosphoribosyltransferase complex
*Quinolinic acid phosphoribosyltransferase complex
Line 170: Line 198:
*'''Adenine phosphoribosyltransferase'''
*'''Adenine phosphoribosyltransferase'''
 +
**[[6hgp]] – hAPRT <br />
**[[1g2p]], [[1g2q]] – yAPRT <br />
**[[1g2p]], [[1g2q]] – yAPRT <br />
**[[1qcc]], [[1qcd]] - LdAPRT – ''Leishmania donovani''<br />
**[[1qcc]], [[1qcd]] - LdAPRT – ''Leishmania donovani''<br />
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**[[4lza]] – APRT – ''Thermoanaerobacter pseudethanolicus''<br />
**[[4lza]] – APRT – ''Thermoanaerobacter pseudethanolicus''<br />
**[[4m0k]] – APRT – ''Rhodothermus marinus''<br />
**[[4m0k]] – APRT – ''Rhodothermus marinus''<br />
-
**[[4mb6]] – YpAPRT – ''Yersinia pseudotuberculosis''<br />
+
**[[4mb6]], [[5y4a]] – YpAPRT – ''Yersinia pseudotuberculosis''<br />
**[[4trb]] – SsAPRT <br />
**[[4trb]] – SsAPRT <br />
 +
**[[5yw2]] - FtAPRT <br />
 +
**[[5zgo]] - TtAPRT <br />
*Adenine phosphoribosyltransferase complex
*Adenine phosphoribosyltransferase complex
-
**[[1ore]], [[1zn8]], [[1zn9]] - hAPRT + AMP<br />
+
**[[1ore]], [[1zn8]], [[1zn9]], [[6fcl]] - hAPRT + AMP<br />
**[[4x44]], [[4x45]] - hAPRT (mutant) + AMP <br />
**[[4x44]], [[4x45]] - hAPRT (mutant) + AMP <br />
-
**[[1zn7]] - hHGPRT + adenine + PRPP<BR />
+
**[[6hgr]] - hAPRT + IMP<br />
 +
**[[6hgs]] - hAPRT + GMP<br />
 +
**[[6fch]] - hHGPRT + PRPP<BR />
 +
**[[1zn7]], [[6fci]] - hHGPRT + adenine + PRPP<BR />
 +
**[[6hgq]] - hHGPRT + hypoxanthine + PRPP<BR />
 +
**[[6fd6]], [[6fd5]], [[6fd4]] - hHGPRT (mutant) + adenine + PRPP<BR />
 +
**[[5vjp]], [[5vjn]] – yAPRT1 + adenine + DIAB<br />
 +
**[[5yw5]] - FtAPRT + adenine<br />
**[[1qb7]] - LdAPRT + adenine<br />
**[[1qb7]] - LdAPRT + adenine<br />
**[[1qb8]] - LdAPRT + AMP<br />
**[[1qb8]] - LdAPRT + AMP<br />
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**[[4ts5]] - SsAPRT + AMP<br />
**[[4ts5]] - SsAPRT + AMP<br />
**[[5b6h]] - YpAPRT + AMP <br />
**[[5b6h]] - YpAPRT + AMP <br />
 +
**[[5zoc]], [[5znq]], [[5zmi]], [[5zc7]] - YpAPRT + adenine <br />
 +
**[[5y07]] - YpHGPRT + PRPP<BR />
**[[1mzv]] - LtAPRT + AMP<br />
**[[1mzv]] - LtAPRT + AMP<br />
**[[4ts7]] - SsAPRT + ADP<br />
**[[4ts7]] - SsAPRT + ADP<br />
Line 198: Line 238:
**[[4kqh]] - StNN:DBI PRT (mutant)<br />
**[[4kqh]] - StNN:DBI PRT (mutant)<br />
**[[1wx1]] – TtNN:DBI PRT <br />
**[[1wx1]] – TtNN:DBI PRT <br />
-
**[[3u4g]] – PhNN:DBI PRT
+
**[[3u4g]] – PhNN:DBI PRT<br />
 +
**[[6b5f]] – NN:DBI – ''Yersinia enterocolitica''<br />
*Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase complex
*Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase complex
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**[[4hkm]] - ANPRT – ''Xanthomonas campestris''<br />
**[[4hkm]] - ANPRT – ''Xanthomonas campestris''<br />
**[[4gtn]] – AcANPRT – ''Acinetobacter''<br />
**[[4gtn]] – AcANPRT – ''Acinetobacter''<br />
 +
**[[5nof]], [[5noe]] – ANPRT – ''Thermococcus kodkarensis''<br />
*Anthranilate phosphoribosyltransferase complex containing anthranilate
*Anthranilate phosphoribosyltransferase complex containing anthranilate
-
**[[4owm]], [[4own]], [[4owo]], [[4owq]], [[4ows]], [[4owu]], [[4n5v]], 4n93]] - MtANPRT + PRPP + anthranilate derivative<BR />
+
**[[4owm]], [[4own]], [[4owo]], [[4owq]], [[4ows]], [[4owu]], [[4n5v]], [[4n93]] - MtANPRT + PRPP + anthranilate derivative<BR />
**[[4ij1]], [[4m0r]], [[4owv]], [[4n8q]] - MtANPRT + anthranilate derivative <br />
**[[4ij1]], [[4m0r]], [[4owv]], [[4n8q]] - MtANPRT + anthranilate derivative <br />
**[[4x5d]] - MtANPRT (mutant) + anthranilate<BR />
**[[4x5d]] - MtANPRT (mutant) + anthranilate<BR />
Line 288: Line 330:
**[[2e5d]] - hNMPRT + nicotinamide<br />
**[[2e5d]] - hNMPRT + nicotinamide<br />
**[[3dgr]] - hNMPRT + ADP analog<br />
**[[3dgr]] - hNMPRT + ADP analog<br />
-
**[[4jnm]], [[4jr5]], [[4kfn]], [[4kfo]], [[4kfp]], [[4lts]], [[4lv9]], [[4lva]], [[4lvb]], [[4lvd]], [[4lvf]], [[4lvg]], [[4lww]], [[4m6p]], [[4m6q]], [[4n9b]], [[4n9c]], [[4n9d]], [[4n9e]], [[4l4l]], [[4l4m]], [[4o0z]], [[4o10]], [[4o12]], [[4o13]], [[4o14]], [[4o15]], [[4o16]], [[4o17]], [[4o18]], [[4o19]], [[4o1a]], [[4o1b]], [[4o1c]], [[4o1d]], [[4wq6]], [[4o28]], [[5kit]], [[5u2m]], [[5u2n]], [[5upe]], [[5upf]] - hNMPRT + inhibitor<br />
+
**[[4jnm]], [[4jr5]], [[4kfn]], [[4kfo]], [[4kfp]], [[4lts]], [[4lv9]], [[4lva]], [[4lvb]], [[4lvd]], [[4lvf]], [[4lvg]], [[4lww]], [[4m6p]], [[4m6q]], [[4n9b]], [[4n9c]], [[4n9d]], [[4n9e]], [[4l4l]], [[4l4m]], [[4o0z]], [[4o10]], [[4o12]], [[4o13]], [[4o14]], [[4o15]], [[4o16]], [[4o17]], [[4o18]], [[4o19]], [[4o1a]], [[4o1b]], [[4o1c]], [[4o1d]], [[4wq6]], [[4o28]], [[5kit]], [[5u2m]], [[5u2n]], [[5upe]], [[5upf]], [[6e68]], [[5wi1]], [[5wi0]], [[6b76]], [[6b75]], [[6atb]] - hNMPRT + inhibitor<br />
**[[3dhd]], [[3dhf]] - hNMPRT + pyrophosphate + NMN<BR />
**[[3dhd]], [[3dhf]] - hNMPRT + pyrophosphate + NMN<BR />
**[[3dkj]], [[3dkl]] - hNMPRT + benzamide + PRPP<BR />
**[[3dkj]], [[3dkl]] - hNMPRT + benzamide + PRPP<BR />
 +
**[[5nsd]], [[5lx5]], [[5lx3]] - hNMPRT + piperidine derivative<br />
**[[2h3d]] - mNMPRT + NMN<BR />
**[[2h3d]] - mNMPRT + NMN<BR />
**[[2g96]] - rNMPRT + NMN<BR />
**[[2g96]] - rNMPRT + NMN<BR />

Revision as of 08:48, 21 November 2019

Yeast orotate phosphoribosyltransferase dimer complex with orotate and PRPP (PDB entry 2ps1)

Drag the structure with the mouse to rotate

3D structures of phosphoribosyltransferase

Updated on 21-November-2019

Hypoxanthine-guanine PRT binary complex

References

  1. ↑ Sculley DG, Dawson PA, Emmerson BT, Gordon RB. A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. Hum Genet. 1992 Nov;90(3):195-207. PMID:1487231
  2. ↑ 2.0 2.1 Gonzalez-Segura L, Witte JF, McClard RW, Hurley TD. Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase. Biochemistry. 2007 Dec 11;46(49):14075-86. Epub 2007 Nov 20. PMID:18020427 doi:10.1021/bi701023z
  3. ↑ Foster AC, Whetsell WO Jr, Bird ED, Schwarcz R. Quinolinic acid phosphoribosyltransferase in human and rat brain: activity in Huntington's disease and in quinolinate-lesioned rat striatum. Brain Res. 1985 Jun 17;336(2):207-14. PMID:3159462
  4. ↑ Carter D, Donald RG, Roos D, Ullman B. Expression, purification, and characterization of uracil phosphoribosyltransferase from Toxoplasma gondii. Mol Biochem Parasitol. 1997 Aug;87(2):137-44. PMID:9247925
  5. ↑ . PMID:121011881
  6. ↑ Castell A, Short FL, Evans GL, Cookson TV, Bulloch EM, Joseph DD, Lee CE, Parker EJ, Baker EN, Lott JS. Substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition. Biochemistry. 2013 Jan 30. PMID:23363292 doi:http://dx.doi.org/10.1021/bi301387m
  7. ↑ Pedreno S, Pisco JP, Larrouy-Maumus G, Kelly G, de Carvalho LP. Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase. Biochemistry. 2012 Oct 9;51(40):8027-38. doi: 10.1021/bi300808b. Epub 2012 Sep, 27. PMID:22989207 doi:http://dx.doi.org/10.1021/bi300808b
  8. ↑ Galassi L, Di Stefano M, Brunetti L, Orsomando G, Amici A, Ruggieri S, Magni G. Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis. Biochimie. 2012 Feb;94(2):300-9. doi: 10.1016/j.biochi.2011.06.033. Epub 2011 Jul, 3. PMID:21742010 doi:http://dx.doi.org/10.1016/j.biochi.2011.06.033
  9. ↑ Imai S. Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases. Curr Pharm Des. 2009;15(1):20-8. PMID:19149599
  10. ↑ Tohyama J, Nanba E, Ohno K. Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency: identification of point mutations in Japanese patients with Lesch-Nyhan syndrome and hereditary gout and their permanent expression in an HPRT-deficient mouse cell line. Hum Genet. 1994 Feb;93(2):175-81. PMID:8112742
  11. ↑ Montecucco F, Cea M, Cagnetta A, Damonte P, Nahimana A, Ballestrero A, Del Rio A, Bruzzone S, Nencioni A. Nicotinamide phosphoribosyltransferase as a target in inflammation- related disorders. Curr Top Med Chem. 2013;13(23):2930-8. PMID:24171767

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