Phosphotransferase

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Aminoglycoside phosphotransferase complex with gentamycin, and glycerol (PDB entry 3ham)

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References

↑ Wright GD, Thompson PR. Aminoglycoside phosphotransferases: proteins, structure, and mechanism. Front Biosci. 1999 Jan 1;4:D9-21. PMID:9872733
↑ Mizrachi Nebenzahl Y, Blau K, Kushnir T, Shagan M, Portnoi M, Cohen A, Azriel S, Malka I, Adawi A, Kafka D, Dotan S, Guterman G, Troib S, Fishilevich T, Gershoni JM, Braiman A, Mitchell AM, Mitchell TJ, Porat N, Goliand I, Chalifa Caspi V, Swiatlo E, Tal M, Ellis R, Elia N, Dagan R. Streptococcus pneumoniae Cell-Wall-Localized Phosphoenolpyruvate Protein Phosphotransferase Can Function as an Adhesin: Identification of Its Host Target Molecules and Evaluation of Its Potential as a Vaccine. PLoS One. 2016 Mar 18;11(3):e0150320. doi: 10.1371/journal.pone.0150320., eCollection 2016. PMID:26990554 doi:http://dx.doi.org/10.1371/journal.pone.0150320
↑ Trach K, Burbulys D, Strauch M, Wu JJ, Dhillon N, Jonas R, Hanstein C, Kallio P, Perego M, Bird T, et al.. Control of the initiation of sporulation in Bacillus subtilis by a phosphorelay. Res Microbiol. 1991 Sep-Oct;142(7-8):815-23. PMID:1664534
↑ Noguchi N, Takada K, Katayama J, Emura A, Sasatsu M. Regulation of transcription of the mph(A) gene for macrolide 2'-phosphotransferase I in Escherichia coli: characterization of the regulatory gene mphR(A). J Bacteriol. 2000 Sep;182(18):5052-8. PMID:10960087
↑ Shiba T, Itoh H, Kameda A, Kobayashi K, Kawazoe Y, Noguchi T. Polyphosphate:AMP phosphotransferase as a polyphosphate-dependent nucleoside monophosphate kinase in Acinetobacter johnsonii 210A. J Bacteriol. 2005 Mar;187(5):1859-65. PMID:15716459 doi:http://dx.doi.org/10.1128/JB.187.5.1859-1865.2005
↑ Young PG, Walanj R, Lakshmi V, Byrnes LJ, Metcalf P, Baker EN, Vakulenko SB, Smith CA. The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2-phosphotransferase-IIa [APH(2)-IIa] provide insights into substrate selectivity in the APH(2) subfamily. J Bacteriol. 2009 Jul;191(13):4133-43. Epub 2009 May 8. PMID:19429619 doi:10.1128/JB.00149-09

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Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Phosphotransferase"

Category: Topic Page

@@ Line 1: / Line 1: @@
 <StructureSection load='' size='350' side='right' caption='Aminoglycoside phosphotransferase complex with gentamycin, and glycerol (PDB entry [[3ham]])' scene='45/456502/Cv/1'>
+__TOC__
 == Function ==
 '''Phosphotransferase''' (PT) are enzymes which catalyze phosphorylation reactions.  The acceptor group can be alcohol, carboxy, nitrogenous, phosphate or a pair ofd groups.<br />
@@ Line 21: / Line 23: @@
 </StructureSection>
-==3D structures of phosphotransferase==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*'''Phosphotransferase'''
-**[[1fyn]] – PT fyn SH3 domain + polyproline peptide - human<br />
-**[[1c02]] - PT - yeast<br />
-**[[3our]] – PT IIA + pyruvate decarboxylase – ''Vibrio vulnificus''<BR />
-**[[2l5h]], [[2kx9]] - EcPT I - ''Escherichia coli'' – NMR<BR />
-**[[2xdf]] - EcPT I+ phosphocarrier protein HPR – NMR<BR />
-**[[3oxp]] – PT II – ''Yersinia pestis''<BR />
-**[[3ci6]] – PT GAF domain – ''Acinetobacter''<BR />
-**[[2ooc]], [[4fpp]] – PT histidine – ''Caulobacter crescentus''<BR />
-**[[3ipj]] – PT IIABC – ''Clostridium difficile''<BR />
-**[[2f9h]] - EfPT IIA – ''Enterococcus faecalis''<BR />
-**[[3n9x]] – PT – ''Plasmodium berghei''<br />
-**[[4qpk]] – BaPT – ''Brucella abortus''<br />
-**[[4qpj]] – BaPT + CTRA<br />
-*'''Aminoglycoside phosphotransferase'''
-**[[3tyk]] - EcAGPT IA<BR />
-**[[3uzr]] - EcAGPT IB<BR />
-**[[3q2m]], [[3i1a]] – LpAGPT IA – ''Legionella pneumophila''<BR />
-**[[1nd4]] – KpAGPT IIA – ''Klebsiella pneumoniae''<BR />
-**[[1qhn]] – SvAGPT – ''Streptomyces venezuelae''<BR />
-**[[3sgc]], [[3n4t]], [[3n4u]], [[3n4v]] ,[[4dbx]], [[4de4]]  - EncAGPT ID – ''Enterococcus casseliflavus''<BR />
-**[[1j7i]] - EfAGPT IIIA <br />
-**[[4h05]], [[6fuc]] – PT VIII – ''Streptomyces rimosus''<br />
-**[[4pdy]] – PT – ''Alicyclobacillus acidocaldarius''<br />
-**[[6ef6]] – PT – ''Mycobacterium smegmatis''<br />
-*Aminoglycoside phosphotransferase complex with nucleotide
-**[[4dca]] - EcAGPT IB + ADP<BR />
-**[[1qhx]] - SvAGPT + ATP<BR />
-**[[3i0q]] - LpAGPT IA + AMP<BR />
-**[[1j7l]] - EfAGPT IIIA + ADP <BR />
-**[[1j7u]] - EfAGPT IIIA + AMP-PNP <br />
-**[[4ej7]] - AGPT IA + ATP – ''Acinetobacter baumanii''<br />
-**[[4dt8]], [[4dt9]] - EncAGPT ID + nucleotide<br />
-**[[4dta]], [[4dtb]] - EncAGPT ID (mutant) + nucleotide
-*Aminoglycoside phosphotransferase complex with antibiotic
-**[[3ham]] - EfAGPT + antibiotic <BR />
-**[[3hav]] - EfAGPT + ATP + antibiotic <BR />
-**[[3tm0]] - EfAGPT + AMP-PNP + antibiotic<br />
-**[[2b0q]], [[1l8t]] - EfAGPT IIIA + ADP + antibiotic<br />
-**[[1grq]], [[1grr]], [[1qhs]] - SvAGPT + antibiotic<br />
-**[[1qhy]] - SvAGPT + ATPγ + antibiotic<br />
-**[[3sg8]], [[3sg9]], [[4dfb]], [[4dfu]] - EncAGPT ID + antibiotic<br />
-**[[3i0o]] - LpAGPT IA + ADP + antibiotic<br />
-**[[4feu]], [[4fev]], [[4few]], [[4fex]], [[4gkh]], [[4gki]] - LpAGPT IA + inhibitor + antibiotic<br />
-**[[6fux]] - SrAGPT + ADP + antibiotic<br />
-*Aminoglycoside phosphotransferase complex with inhibitor
-**[[2bkk]], [[3q2j]] - EfAGPT IIIA + inhibitor
-*'''Phosphoenolpyruvate-protein phosphotransferase'''
-**[[2hwg]] - EcPEP<br />
-**[[5t12]] - EcPEP N terminal (mutant)<br />
-**[[3nbm]] – PEP lactose-specific IIBC – ''Streptococcus pneumoniae''<BR />
-**[[2l2q]] - PEP cellbiose-specific IIB – ''Borrelia burgdorferi'' – NMR<br />
-**[[3k1s]] - PEP cellbiose-specific IIA – ''Bacillus anthracis''<br />
-**[[2kyr]] – EcPEP fructose-specific IIB<br />
-**[[2r4q]] - BsPEP fructose-specific IIABC – ''Bacillus subtilis''<br />
-**[[2r48]] - BsPEP fructose-specific IIB<br />
-**[[1vsq]], [[2jzh]], [[2jzn]], [[2jzo]] - EcPEP mannose-specific IIA - NMR<br />
-**[[3bp3]] - EcPEP glucose-specific IIB<br />
-**[[1o53]] - EcPEP glucose-specific IIA N terminal – NMR<br />
-**[[3eye]] - EcPEP acetylgalactosamine-specific IIB<br />
-**[[2oq3]], [[1vrv]] - EcPEP mannitol-specific IIA<br />
-**[[1vkr]] - EcPEP mannitol-specific IIABC – NMR<br />
-**[[2few]] - EcPEP mannitol-specific IIA (mutant)<br />
-**[[1wcr]] - EcPEP diacetylchitobiose-specific IIA (mutant) – NMR<br />
-**[[1h9c]] - EcPEP diacetylchitobiose-specific IIB – NMR<br />
-**[[3ipr]] – EfPEP gluconate-specific IIA<br />
-**[[3bed]] - EfPEP mannose-specific IIA<br />
-**[[1nrz]] - KpPEP sorbose-specific IIB<br />
-**[[2hro]] – PEP – ''Staphylococcus carnosus''<br />
-**[[2wqd]] - PEP (mutant) – ''Staphylococcus aureus''<br />
-**[[3trc]] - PEP (mutant) – ''Coxiella burnetii''<br />
-**[[5woy]] - PEP – ''Caldanaerobacter subterraneus'' - NMR<br />
-*Phosphoenolpyruvate-protein phosphotransferase complex
-**[[2xz7]] – TtPEP PEP-binding domain + phosphoenolpyruvate – ''Thermoanaerobacter tengcongensis''<BR />
-**[[2xz9]] - TtPEP PEP-binding domain + pyruvate<BR />
-**[[1ggr ]]- EcPEP glucose-specific IIA + phosphocarrier protein HPR – NMR<br />
-**[[3bp8]] - EcPEP glucose-specific IIB + NAGC-like transcriptional regulator<br />
-**[[1j6t]] - EcPEP mannitol-specific IIABC + phosphocarrier protein HPR – NMR<br />
-**[[5t1o]] - EcPEP + phosphocarrier protein NPR<br />
-**[[2mp0]] – EcPEP N terminal + EcPEP glucose-specific IIA<br />
-**[[4jbw]] – EcPEP glucose-specific IIA + Malf + Malg + Malk<br />
-*'''Sporulation initiation phosphotransferase'''
-**[[1f51]] – BsSpo0B + Spo0F<br />
-**[[2ftk]] – BsSpo0B + Spo0F (mutant)<br />
-**[[1pey]], [[1nat]] – BsPT Spo0F<br />
-**[[1srr]] - BsPT Spo0F (mutant) <br />
-**[[1pux]], [[1fsp]], [[2fsp]] - BsPT Spo0F – NMR<br />
-**[[2jvi]], [[2jvj]], [[2jvk]] - BsPT Spo0F (mutant) – NMR<br />
-**[[3q15]] - BsPT spo0F + response regulator aspartate phosphatase<br />
-**[[6ifh]] – SpoF - ''Paenisporosarcina''<br />
-*'''Microlide 2”-phosphotransferase'''
-**[[5igh]] – EcMPT I <br />
-**[[5igi]], [[5igj]], [[5igs]], [[5igt]] – EcMPT I  + antibiotic + guanosine<br />
-**[[5igp]], [[5igr]] – EcMPT I  + antibiotic + GDP<br />
-**[[5uxb]] – BfMPT II – ''Brachybacterium faecium'' <br />
-**[[5uxd]] – BfMPT II  + antibiotic<br />
-**[[5uxa]], [[5igu]] – EcMPT II <br />
-**[[5iwu]] – EcMPT II  + antibiotic<br />
-**[[5ih1]], [[5igv]], [[5igw]], [[5igy]], [[5igz]] – EcMPT II  + antibiotic + GDP<br />
-**[[5ih0]] – EcMPT II (mutant) + antibiotic + GDP<br />
-*'''Polyphosphate:AMP phosphotransferase or polyphosphate kinase'''
-**[[5lc9]] – MrPAPT – ''Meiothermus ruber'' <br />
-**[[5o6k]] – MrPAPT (mutant)  <br />
-**[[5lcd]] – MrPAPT + AMP <br />
-**[[5ld1]] – MrPAPT + ATP <br />
-**[[5o6m]] – MrPAPT (mutant) + ATP <br />
-**[[5ldb]], [[5maq]] – MrPAPT + ADP <br />
-**[[6dzg]] – PAPT + ADP – ''Rhizobium meliloti''<br />
-**[[6au0]], [[6aqn]] – ChPAPT + inhibitor – ''Cytophaga hutchinsonii'' <br />
-**[[6anh]] – ChPAPT + guanosine tetraphosphate <br />
-**[[6ang]] – ChPAPT + AMP <br />
-**[[6an9]] – ChPAPT + ADP <br />
-*Rifampin phosphotransferase
-**[[5hv6]] – LmPAPT – ''Listeria monocytogenes''<br />
-**[[5hv2]] – LmPAPT (mutant) <br />
-**[[5hv3]] – LmPAPT (mutant) + AMPPNP<br />
-**[[5hv1]] – LmPAPT + AMPPNP + rifampin<br />
-*CDP-alcohol phosphotransferase
-**[[4q7c]] – AfPAPT – ''Archaeoglobus fulgidus''<br />
-**[[4o6n]] – AfPAPT + CDP <br />
-**[[4o6m]] – AfPAPT + CMP <br />
-}}
 == References ==
 <references/>
 [[Category: Topic Page]]

Phosphotransferase

From Proteopedia

Revision as of 09:59, 21 November 2019

Contents

Function

Structural highlights

3D structures of phosphotransferase

References

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