Porphobilinogen synthase
From Proteopedia
(Difference between revisions)
| Line 17: | Line 17: | ||
*Porphobilinogen synthase | *Porphobilinogen synthase | ||
| + | **[[1pv8]] – hPBS (mutant) – human<br /> | ||
| + | **[[2z0i]], [[2z1b]] - PBS - mouse<br /> | ||
**[[1aw5]] – yPBS (mutant) + Zn – yeast<br /> | **[[1aw5]] – yPBS (mutant) + Zn – yeast<br /> | ||
**[[1qml]] - yPBS + Hg<br /> | **[[1qml]] - yPBS + Hg<br /> | ||
**[[1qnv]] - yPBS + Pb<br /> | **[[1qnv]] - yPBS + Pb<br /> | ||
| - | **[[1pv8]] – hPBS (mutant) – human<br /> | ||
| - | **[[2z0i]], [[2z1b]] - PBS - mouse<br /> | ||
**[[1w54]], [[1w56]], [[1w5m]], [[1w5n]], [[1w5o]], [[1w5p]], [[1w5q]] - PaPBS (mutant) + Mg + Zn – ''Pseudomonas aeruginosa'' | **[[1w54]], [[1w56]], [[1w5m]], [[1w5n]], [[1w5o]], [[1w5p]], [[1w5q]] - PaPBS (mutant) + Mg + Zn – ''Pseudomonas aeruginosa'' | ||
*Porphobilinogen synthase complex | *Porphobilinogen synthase complex | ||
| - | **[[ | + | **[[1e51]] - hPBS + PBG + Zn<br /> |
| - | + | ||
**[[1ylv]], [[1h7n]] - yPBS + LA + Zn<br /> | **[[1ylv]], [[1h7n]] - yPBS + LA + Zn<br /> | ||
**[[1w31]] - yPBS + LA derivative + Zn<br /> | **[[1w31]] - yPBS + LA derivative + Zn<br /> | ||
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**[[1h7r]], [[1h7p]], [[1eb3]], [[1gjp]] - yPBS + inhibitor + Zn<br /> | **[[1h7r]], [[1h7p]], [[1eb3]], [[1gjp]] - yPBS + inhibitor + Zn<br /> | ||
**[[1ohl]] - yPBS + intermediate + Zn<br /> | **[[1ohl]] - yPBS + intermediate + Zn<br /> | ||
| + | **[[1b4e]] - EcPBS + LA + Zn – ''Escherichia coli''<br /> | ||
**[[1i8j]], [[1l6s]], [[1l6y]] - EcPBS + inhibitor + Mg + Zn<br /> | **[[1i8j]], [[1l6s]], [[1l6y]] - EcPBS + inhibitor + Mg + Zn<br /> | ||
**[[2c1h]] - PBS + inhibitor + Mg – ''Chlorobium vibrioforme'' <br /> | **[[2c1h]] - PBS + inhibitor + Mg – ''Chlorobium vibrioforme'' <br /> | ||
**[[2c13]], [[2c14]] - PaPBS (mutant) + inhibitor + Mg<br /> | **[[2c13]], [[2c14]] - PaPBS (mutant) + inhibitor + Mg<br /> | ||
**[[2c15]], [[2c16]], [[2c18]], [[2c19]] - PaPBS + inhibitor + Mg<br /> | **[[2c15]], [[2c16]], [[2c18]], [[2c19]] - PaPBS + inhibitor + Mg<br /> | ||
| - | **[[ | + | **[[1b4k]] - PaPBS + LA + Zn<br /> |
**[[1gzg]] - PaPBS + LA derivative + Mg<br /> | **[[1gzg]] - PaPBS + LA derivative + Mg<br /> | ||
**[[2woq]] - PaPBS + antibiotic + Mg<br /> | **[[2woq]] - PaPBS + antibiotic + Mg<br /> | ||
Revision as of 10:45, 25 November 2019
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3D structures of porphobilinogen synthase
Updated on 25-November-2019
References
- ↑ Jaffe EK. The porphobilinogen synthase catalyzed reaction mechanism. Bioorg Chem. 2004 Oct;32(5):316-25. PMID:15381398 doi:http://dx.doi.org/10.1016/j.bioorg.2004.05.010
- ↑ Doss M, Muller WA. Acute lead poisoning in inherited porphobilinogen synthase (delta-aminolevulinic acid dehydrase) deficiency. Blut. 1982 Aug;45(2):131-9. PMID:7104498
- ↑ Erskine PT, Newbold R, Brindley AA, Wood SP, Shoolingin-Jordan PM, Warren MJ, Cooper JB. The x-ray structure of yeast 5-aminolaevulinic acid dehydratase complexed with substrate and three inhibitors. J Mol Biol. 2001 Sep 7;312(1):133-41. PMID:11545591 doi:10.1006/jmbi.2001.4947
