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== Function(s) and Biological Relevance == IMP (Inosin-5’-monophosphate) dehydrogenase is an enzyme that catalyzes rate limiting step in the de novo guanine nucleotide biosynthetic pathway. It comes from a fungus known as Ashbya gossip and it is particularly interesting because of the major affect cations, like potassium have on it. IMPDH facilitates these conformational changes. It represents a therapeutic mechanism for managing several diseases including microbial infections and cancer. Furthermore, dinucleotide polyphosphates play important physiological roles in the allosteric regulation, which may have important implications for the design of therapeutic strategies to inhibit IMPDH’s as well.

Broader Implications

In a recent study done by Lizbeth Hedstrom, she mentioned how "pacemaker" enzymes, such as IMPDH are linked to neoplastic transformation and progression. Researchers discovered that if there were a way for these enzymes to become inhibited, then the growth of the tumors could be regulated and the rate of being metastasized could be controlled.

Structural highlights and structure-function relationships

Energy Transformation

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