This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
176d
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:176d.jpg|left|200px]] | [[Image:176d.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_176d", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_176d| PDB=176d | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA''' | '''NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA''' | ||
| Line 19: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=176D OCA]. | |
==Reference== | ==Reference== | ||
NMR solution structure of a peptide nucleic acid complexed with RNA., Brown SC, Thomson SA, Veal JM, Davis DG, Science. 1994 Aug 5;265(5173):777-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7519361 7519361] | NMR solution structure of a peptide nucleic acid complexed with RNA., Brown SC, Thomson SA, Veal JM, Davis DG, Science. 1994 Aug 5;265(5173):777-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7519361 7519361] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Brown, S C.]] | [[Category: Brown, S C.]] | ||
[[Category: Veal, J M.]] | [[Category: Veal, J M.]] | ||
| - | [[Category: | + | [[Category: Double helix]] |
| - | [[Category: | + | [[Category: Nmr]] |
| - | [[Category: | + | [[Category: Pna]] |
| - | [[Category: | + | [[Category: Rna]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:33:20 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:33, 2 May 2008
NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA
Overview
Peptide nucleic acids (PNA) incorporating nucleic acid bases into an achiral polyamide backbone bind to DNA in a sequence-dependent manner. The structure of a PNA-ribonucleic acid (RNA) complex was determined with nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex with a complementary RNA that is an antiparallel, right-handed double helix with Watson-Crick base pairing similar to the "A" form structure of RNA duplexes. The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure-based design of antisense agents.
About this Structure
Full crystallographic information is available from OCA.
Reference
NMR solution structure of a peptide nucleic acid complexed with RNA., Brown SC, Thomson SA, Veal JM, Davis DG, Science. 1994 Aug 5;265(5173):777-80. PMID:7519361 Page seeded by OCA on Fri May 2 09:33:20 2008
Categories: Brown, S C. | Veal, J M. | Double helix | Nmr | Pna | Rna
