6i7x

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m (Protected "6i7x" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6i7x is ON HOLD
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==Crystal Structure of the first bromodomain of BRD4 in complex with RT53==
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<StructureSection load='6i7x' size='340' side='right'caption='[[6i7x]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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Authors: Picaud, S., Traquete, R., Bernardes, G.J.L., Newman, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Filippakopoulos, P., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6i7x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I7X FirstGlance]. <br>
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Description: Crystal Structure of the first bromodomain of BRD4 in complex with RT53
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H7B:2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-1-[4-(dimethylamino)piperidin-1-yl]ethanone'>H7B</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i7x OCA], [http://pdbe.org/6i7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i7x RCSB], [http://www.ebi.ac.uk/pdbsum/6i7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i7x ProSAT]</span></td></tr>
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[[Category: Arrowsmith, C.H]]
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</table>
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[[Category: Bernardes, G.J.L]]
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== Disease ==
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[[Category: Traquete, R]]
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[[Category: Picaud, S]]
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== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bernardes, G J.L]]
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[[Category: Bountra, C]]
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[[Category: Edwards, A M]]
[[Category: Filippakopoulos, P]]
[[Category: Filippakopoulos, P]]
[[Category: Newman, J]]
[[Category: Newman, J]]
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[[Category: Edwards, A.M]]
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[[Category: Picaud, S]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Structural genomic]]
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[[Category: Bountra, C]]
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[[Category: Traquete, R]]
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[[Category: Bet]]
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[[Category: Bromodomain]]
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[[Category: Inhibitor]]
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[[Category: Rt53]]
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[[Category: Sgc]]
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[[Category: Transcription]]

Revision as of 06:43, 27 November 2019

Crystal Structure of the first bromodomain of BRD4 in complex with RT53

PDB ID 6i7x

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