6ida

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'''Unreleased structure'''
 
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The entry 6ida is ON HOLD until Paper Publication
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==Crystal structure of H7 hemagglutinin mutant H7-SVTQ ( A138S, P221T, L226Q) from the influenza virus A/Anhui/1/2013 (H7N9)==
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<StructureSection load='6ida' size='340' side='right'caption='[[6ida]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6ida]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IDA FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ida FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ida OCA], [http://pdbe.org/6ida PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ida RCSB], [http://www.ebi.ac.uk/pdbsum/6ida PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ida ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/R4NN21_9INFA R4NN21_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Gao, G F]]
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[[Category: Qi, J X]]
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[[Category: Xu, Y]]
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[[Category: H7n9]]
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[[Category: Hemagglutinin]]
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[[Category: Influenza virus]]
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[[Category: Viral protein]]

Revision as of 06:45, 27 November 2019

Crystal structure of H7 hemagglutinin mutant H7-SVTQ ( A138S, P221T, L226Q) from the influenza virus A/Anhui/1/2013 (H7N9)

PDB ID 6ida

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OCA

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