6kxw

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m (Protected "6kxw" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6kxw is ON HOLD
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==Crystal structure of human aquaporin AQP7 in bound to glycerol==
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<StructureSection load='6kxw' size='340' side='right'caption='[[6kxw]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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Authors: Zhang, L., Yao, D., Zhou, F., Zhang, Q., Zhou, L., Cao, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6kxw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KXW FirstGlance]. <br>
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Description: A human solute channel in bound to substrate
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kxw OCA], [http://pdbe.org/6kxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kxw RCSB], [http://www.ebi.ac.uk/pdbsum/6kxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kxw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN]] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Cao, Y]]
[[Category: Cao, Y]]
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[[Category: Yao, D]]
[[Category: Zhang, L]]
[[Category: Zhang, L]]
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[[Category: Yao, D]]
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[[Category: Zhang, Q]]
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[[Category: Zhou, F]]
[[Category: Zhou, L]]
[[Category: Zhou, L]]
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[[Category: Zhou, F]]
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[[Category: Aquaporin]]
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[[Category: Zhang, Q]]
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[[Category: Lipid metabolism]]
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[[Category: Membrane protein]]
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[[Category: Transporter]]

Revision as of 06:48, 27 November 2019

Crystal structure of human aquaporin AQP7 in bound to glycerol

PDB ID 6kxw

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