6mxx
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC2991== | |
| - | + | <StructureSection load='6mxx' size='340' side='right'caption='[[6mxx]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6mxx]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MXX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K6P:N-[3-(tert-butylamino)propyl]-3-iodobenzamide'>K6P</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mxx OCA], [http://pdbe.org/6mxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mxx RCSB], [http://www.ebi.ac.uk/pdbsum/6mxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mxx ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Botuyan, M V]] | ||
| + | [[Category: Cui, G]] | ||
| + | [[Category: Mer, G]] | ||
| + | [[Category: Class switch recombination]] | ||
| + | [[Category: Dna damage response]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Small molecule inhibitor]] | ||
| + | [[Category: Tandem tudor domain]] | ||
Revision as of 06:49, 27 November 2019
Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC2991
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