6n54
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidocytidine monophosphate== | |
| - | + | <StructureSection load='6n54' size='340' side='right'caption='[[6n54]], [[Resolution|resolution]] 2.42Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6n54]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N54 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N54 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KEA:2-azido-2-deoxycytidine+5-(dihydrogen+phosphate)'>KEA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_kinase Uridine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.48 2.7.1.48] </span></td></tr> |
| - | [[Category: Cuthbert, B | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n54 OCA], [http://pdbe.org/6n54 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n54 RCSB], [http://www.ebi.ac.uk/pdbsum/6n54 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n54 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/UCK2_HUMAN UCK2_HUMAN]] Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Uridine kinase]] | ||
| + | [[Category: Cuthbert, B J]] | ||
| + | [[Category: Goulding, C W]] | ||
[[Category: Nainar, S]] | [[Category: Nainar, S]] | ||
| - | [[Category: | + | [[Category: Spitale, R C]] |
| - | [[Category: | + | [[Category: Azide]] |
| + | [[Category: Complex]] | ||
| + | [[Category: Cytosolic protein]] | ||
| + | [[Category: Kinase]] | ||
| + | [[Category: Uck2]] | ||
| + | [[Category: Uridine-cytidine kinase 2]] | ||
Revision as of 06:49, 27 November 2019
Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidocytidine monophosphate
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