6qzi
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Aquaporin 7 at 1.9 A resolution== | |
| - | + | <StructureSection load='6qzi' size='340' side='right'caption='[[6qzi]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6qzi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QZI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qzi OCA], [http://pdbe.org/6qzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qzi RCSB], [http://www.ebi.ac.uk/pdbsum/6qzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qzi ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN]] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Eltschkner, S]] | [[Category: Eltschkner, S]] | ||
[[Category: Lindkvist-Petersson, K]] | [[Category: Lindkvist-Petersson, K]] | ||
| + | [[Category: Mare, S W.H de]] | ||
| + | [[Category: Venskutonyte, R]] | ||
| + | [[Category: Aquaglyceroporin]] | ||
| + | [[Category: Glycerol channel]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 06:56, 27 November 2019
Crystal structure of human Aquaporin 7 at 1.9 A resolution
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