6qzj

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'''Unreleased structure'''
 
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The entry 6qzj is ON HOLD until Paper Publication
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==Crystal structure of human Aquaporin 7 at 2.2 A resolution==
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<StructureSection load='6qzj' size='340' side='right'caption='[[6qzj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors: de Mare, S.W.-H., Venskutonyte, R., Eltschkner, S., Lindkvist-Petersson, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6qzj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QZJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QZJ FirstGlance]. <br>
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Description: Crystal structure of human Aquaporin 7 at 2.2 A resolution
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6qzi|6qzi]]</td></tr>
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[[Category: De Mare, S.W.-H]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qzj OCA], [http://pdbe.org/6qzj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qzj RCSB], [http://www.ebi.ac.uk/pdbsum/6qzj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qzj ProSAT]</span></td></tr>
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[[Category: Venskutonyte, R]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN]] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Eltschkner, S]]
[[Category: Eltschkner, S]]
[[Category: Lindkvist-Petersson, K]]
[[Category: Lindkvist-Petersson, K]]
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[[Category: Mare, S W.H de]]
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[[Category: Venskutonyte, R]]
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[[Category: Aquaglyceroporin]]
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[[Category: Glycerol channel]]
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[[Category: Membrane protein]]

Revision as of 06:56, 27 November 2019

Crystal structure of human Aquaporin 7 at 2.2 A resolution

PDB ID 6qzj

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