6s8k
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure, Thermodynamics, and Kinetics of Plinabulin Binding to two Tubulin Isotypes== | |
| - | + | <StructureSection load='6s8k' size='340' side='right'caption='[[6s8k]], [[Resolution|resolution]] 1.52Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6s8k]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S8K FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PN6:(3Z,6Z)-3-BENZYLIDENE-6-[(5-TERT-BUTYL-1H-IMIDAZOL-4-YL)METHYLIDENE]PIPERAZINE-2,5-DIONE'>PN6</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8k OCA], [http://pdbe.org/6s8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8k RCSB], [http://www.ebi.ac.uk/pdbsum/6s8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8k ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Olieric, N]] | ||
| + | [[Category: Sharma, A]] | ||
| + | [[Category: Steinmetz, M]] | ||
| + | [[Category: Cancer]] | ||
| + | [[Category: Microtubule]] | ||
| + | [[Category: Microtubule targeting agent]] | ||
| + | [[Category: Structural protein]] | ||
| + | [[Category: Tubulin]] | ||
Current revision
Structure, Thermodynamics, and Kinetics of Plinabulin Binding to two Tubulin Isotypes
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