6svl
From Proteopedia
(Difference between revisions)
m (Protected "6svl" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==human Myeloid-derived growth factor (MYDGF) in complex with neutralizing Fab== | |
| - | + | <StructureSection load='6svl' size='340' side='right'caption='[[6svl]], [[Resolution|resolution]] 1.58Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6svl]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SVL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6svl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6svl OCA], [http://pdbe.org/6svl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6svl RCSB], [http://www.ebi.ac.uk/pdbsum/6svl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6svl ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MYDGF_HUMAN MYDGF_HUMAN]] Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).[UniProtKB:Q9CPT4]<ref>PMID:25581518</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ebenhoch, R]] | ||
| + | [[Category: Nar, H]] | ||
| + | [[Category: Cytokine]] | ||
| + | [[Category: Fab]] | ||
| + | [[Category: Growth factor]] | ||
| + | [[Category: Mydgf]] | ||
| + | [[Category: Neutralizing antibody]] | ||
Revision as of 06:59, 27 November 2019
human Myeloid-derived growth factor (MYDGF) in complex with neutralizing Fab
| |||||||||||
