6uro

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'''Unreleased structure'''
 
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The entry 6uro is ON HOLD until Paper Publication
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==Cryo-EM structure of human CPSF160-WDR33-CPSF30-PAS RNA-CstF77 complex==
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<StructureSection load='6uro' size='340' side='right'caption='[[6uro]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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Authors: Sun, Y., Zhang, Y., Walz, T., Tong, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6uro]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6URO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6URO FirstGlance]. <br>
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Description: Cryo-EM structure of human CPSF160-WDR33-CPSF30-PAS RNA-CstF77 complex
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6urg|6urg]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uro OCA], [http://pdbe.org/6uro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uro RCSB], [http://www.ebi.ac.uk/pdbsum/6uro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uro ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CPSF1_HUMAN CPSF1_HUMAN]] Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.<ref>PMID:14749727</ref> [[http://www.uniprot.org/uniprot/CPSF4_HUMAN CPSF4_HUMAN]] Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).<ref>PMID:9224719</ref> <ref>PMID:14749727</ref> [[http://www.uniprot.org/uniprot/WDR33_HUMAN WDR33_HUMAN]] Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.<ref>PMID:19217410</ref> [[http://www.uniprot.org/uniprot/CSTF3_HUMAN CSTF3_HUMAN]] One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Sun, Y]]
[[Category: Tong, L]]
[[Category: Tong, L]]
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[[Category: Walz, T]]
[[Category: Zhang, Y]]
[[Category: Zhang, Y]]
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[[Category: Walz, T]]
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[[Category: Aauaaa polyadenylation signal]]
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[[Category: Sun, Y]]
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[[Category: Mpsf]]
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[[Category: Pre-mrna 3'-end processing]]
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[[Category: Rna binding]]
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[[Category: Rna binding protein-rna complex]]

Revision as of 07:03, 27 November 2019

Cryo-EM structure of human CPSF160-WDR33-CPSF30-PAS RNA-CstF77 complex

PDB ID 6uro

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