190d

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[[Image:190d.gif|left|200px]]
[[Image:190d.gif|left|200px]]
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{{Structure
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|PDB= 190d |SIZE=350|CAPTION= <scene name='initialview01'>190d</scene>, resolution 1.800&Aring;
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The line below this paragraph, containing "STRUCTURE_190d", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>
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{{STRUCTURE_190d| PDB=190d | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=190d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=190d OCA], [http://www.ebi.ac.uk/pdbsum/190d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=190d RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)'''
'''CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)'''
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==About this Structure==
==About this Structure==
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190D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=190D OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=190D OCA].
==Reference==
==Reference==
Crystal structure of a four-stranded intercalated DNA: d(C4)., Chen L, Cai L, Zhang X, Rich A, Biochemistry. 1994 Nov 22;33(46):13540-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7947764 7947764]
Crystal structure of a four-stranded intercalated DNA: d(C4)., Chen L, Cai L, Zhang X, Rich A, Biochemistry. 1994 Nov 22;33(46):13540-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7947764 7947764]
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[[Category: Protein complex]]
 
[[Category: Cai, L.]]
[[Category: Cai, L.]]
[[Category: Chen, L.]]
[[Category: Chen, L.]]
[[Category: Rich, A.]]
[[Category: Rich, A.]]
[[Category: Zhang, X.]]
[[Category: Zhang, X.]]
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[[Category: base intercalated]]
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[[Category: Base intercalated]]
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[[Category: mismatched]]
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[[Category: Mismatched]]
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[[Category: parallel-stranded tetraplex]]
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[[Category: Parallel-stranded tetraplex]]
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[[Category: quadruple helix]]
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[[Category: Quadruple helix]]
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[[Category: u-dna]]
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[[Category: U-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:34:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:29:47 2008''
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Revision as of 06:34, 2 May 2008

Image:190d.gif

Template:STRUCTURE 190d

CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)


Overview

The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a four-stranded intercalated DNA: d(C4)., Chen L, Cai L, Zhang X, Rich A, Biochemistry. 1994 Nov 22;33(46):13540-6. PMID:7947764 Page seeded by OCA on Fri May 2 09:34:52 2008

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