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Potassium channel toxin
From Proteopedia
(Difference between revisions)
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NMR studies of LqhαIT with a peptide derived from part of neurotoxin receptor site-3 (D4S3-S4) identified residues <scene name='1lqh/Nmr/1'>Lys8, Asn9, Cys12, Val13, Arg18, Trp38, Ala39 and Arg58</scene> of LqhαIT as participating in binding to that extra-cellular part of the sodium channel (3). | NMR studies of LqhαIT with a peptide derived from part of neurotoxin receptor site-3 (D4S3-S4) identified residues <scene name='1lqh/Nmr/1'>Lys8, Asn9, Cys12, Val13, Arg18, Trp38, Ala39 and Arg58</scene> of LqhαIT as participating in binding to that extra-cellular part of the sodium channel (3). | ||
Both methods led to the identification of two regions on the surface of LqhαIT that participate in binding of the toxin to neurotoxin receptor site-3 on sodium channels. | Both methods led to the identification of two regions on the surface of LqhαIT that participate in binding of the toxin to neurotoxin receptor site-3 on sodium channels. | ||
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| + | ==3D structures of potassium channel toxins== | ||
| + | [[Potassium channel toxin 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
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**[[2kfe]] – meucin-24 – NMR<BR /> | **[[2kfe]] – meucin-24 – NMR<BR /> | ||
**[[2ky3]], [[2lu9]] – tamapin - NMR<BR /> | **[[2ky3]], [[2lu9]] – tamapin - NMR<BR /> | ||
| - | **[[2me7]], [[2mel]], [[2men]], [[2meo]] – tamapin (mutant) – NMR<br /> | + | **[[2me7]], [[2mel]], [[2men]], [[2meo]], [[6d3t]], [[6d8h]], [[6d8q]], [[6d8r]], [[6d8s]], [[6d8t]], [[6d8u]], [[6d8y]], [[6d93]], [[6d9o]], [[6d9p]] – tamapin (mutant) – NMR<br /> |
**[[1bah]], [[2crd]] – charybdotoxin - NMR<br /> | **[[1bah]], [[2crd]] – charybdotoxin - NMR<br /> | ||
**[[1cmr]] – charybdotoxin (mutant) - NMR<br /> | **[[1cmr]] – charybdotoxin (mutant) - NMR<br /> | ||
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**[[2a9h]] – charybdotoxin + voltage-gated potassium channel β2 - NMR<br /> | **[[2a9h]] – charybdotoxin + voltage-gated potassium channel β2 - NMR<br /> | ||
**[[1lir]] – LQ2 – NMR<br /> | **[[1lir]] – LQ2 – NMR<br /> | ||
| - | **[[2sn3]] – toxin – Centruroides exilicauda<br /> | + | **[[2sn3]] – toxin – ''Centruroides exilicauda''<br /> |
| - | **[[1ptx]] – toxin – Androctonus australis<br /> | + | **[[1ptx]] – toxin – ''Androctonus australis''<br /> |
| + | **[[6ggz]] – toxin – ''Androctonus mauritanicus'' - NMR<br /> | ||
**[[1lqh]], [[1lqi]] – toxin α – NMR<br /> | **[[1lqh]], [[1lqi]] – toxin α – NMR<br /> | ||
**[[1snb]] – MmBMK M8 – Mesobuthus martensii<br /> | **[[1snb]] – MmBMK M8 – Mesobuthus martensii<br /> | ||
Revision as of 08:48, 27 November 2019
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3D structures of potassium channel toxins
Updated on 27-November-2019
