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Pre-mRNA-splicing factor
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<scene name='46/462200/Cv/3'>Prp8 is a multi-domain protein containing an RNA-binding domain and a Jab1/MPN domain</scene>. | <scene name='46/462200/Cv/3'>Prp8 is a multi-domain protein containing an RNA-binding domain and a Jab1/MPN domain</scene>. | ||
| + | |||
| + | == 3D Structures of pre-mRNA splicing factors == | ||
| + | [[Pre-mRNA splicing factors 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
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*Pre-mRNA-splicing factor 8 | *Pre-mRNA-splicing factor 8 | ||
| + | **[[3lru]] – hPrp residues 1831-1990<br /> | ||
| + | **[[3e9l]], [[3enb]] – hPrp endonuclease domain<br /> | ||
**[[3sbt]], [[4ilh]] – yPrp RNAseH like domain + A1 cistron-splicing factor AAR2 <br /> | **[[3sbt]], [[4ilh]] – yPrp RNAseH like domain + A1 cistron-splicing factor AAR2 <br /> | ||
**[[4jk7]], [[4jk9]], [[3e9o]], [[3e9p]], [[3e66]] - yPrp RNA-binding domain <br /> | **[[4jk7]], [[4jk9]], [[3e9o]], [[3e9p]], [[3e66]] - yPrp RNA-binding domain <br /> | ||
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**[[4kit]] – yPrp Jab1/MPN domain + U5 small nuclear ribonucleoprotein helicase <br /> | **[[4kit]] – yPrp Jab1/MPN domain + U5 small nuclear ribonucleoprotein helicase <br /> | ||
**[[4ilg]] – yPrp Jab1/MPN+RNA-binding domains + A1 cistron-splicing factor AAR2 <br /> | **[[4ilg]] – yPrp Jab1/MPN+RNA-binding domains + A1 cistron-splicing factor AAR2 <br /> | ||
| - | **[[3lru]] – hPrp residues 1831-1990<br /> | ||
| - | **[[3e9l]], [[3enb]] – hPrp endonuclease domain<br /> | ||
**[[2p8r]] – CePrp C terminal (mutant) – ''Caenorhabditis elegans''<br /> | **[[2p8r]] – CePrp C terminal (mutant) – ''Caenorhabditis elegans''<br /> | ||
**[[2p87]] – CePrp C terminal <br /> | **[[2p87]] – CePrp C terminal <br /> | ||
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*Pre-mRNA-splicing factor 20 | *Pre-mRNA-splicing factor 20 | ||
| - | **[[2i2y]] – Prp RNA-binding domain + RNA – ''Streptococcus'' – NMR<BR /> | ||
**[[2i38]] - hPrp RNA-binding domain (mutant) – NMR<BR /> | **[[2i38]] - hPrp RNA-binding domain (mutant) – NMR<BR /> | ||
| + | **[[2i2y]] – Prp RNA-binding domain + RNA – ''Streptococcus'' – NMR<BR /> | ||
*Pre-mRNA-splicing factor 21 | *Pre-mRNA-splicing factor 21 | ||
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*Pre-mRNA-splicing factors in spliceosome | *Pre-mRNA-splicing factors in spliceosome | ||
| + | **[[3jcr]], [[5o9z]] – hPrp - CryoEM<br /> | ||
**[[3jb9]] – yPrp <br /> | **[[3jb9]] – yPrp <br /> | ||
**[[3jcm]], [[5gam]], [[5gan]], [[5gao]], [[5gap]], [[5gmk]], [[5lj3]], [[5lj5]], [[5lqw]], [[5mps]], [[5mq0]], [[5mqf]], [[5wsg]], [[6g90]], [[6exn]], [[6bk8]], [[5ylz]], [[5y88]] – yPrp - CryoEM<br /> | **[[3jcm]], [[5gam]], [[5gan]], [[5gao]], [[5gap]], [[5gmk]], [[5lj3]], [[5lj5]], [[5lqw]], [[5mps]], [[5mq0]], [[5mqf]], [[5wsg]], [[6g90]], [[6exn]], [[6bk8]], [[5ylz]], [[5y88]] – yPrp - CryoEM<br /> | ||
| - | **[[3jcr]], [[5o9z]] – hPrp - CryoEM<br /> | ||
*Pre-mRNA-splicing factor cwc2 | *Pre-mRNA-splicing factor cwc2 | ||
Revision as of 08:56, 27 November 2019
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3D Structures of pre-mRNA splicing factors
Updated on 27-November-2019
References
- ↑ Misteli T, Spector DL. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. Mol Cell. 1999 Jun;3(6):697-705. PMID:10394358
- ↑ McKie AB, McHale JC, Keen TJ, Tarttelin EE, Goliath R, van Lith-Verhoeven JJ, Greenberg J, Ramesar RS, Hoyng CB, Cremers FP, Mackey DA, Bhattacharya SS, Bird AC, Markham AF, Inglehearn CF. Mutations in the pre-mRNA splicing factor gene PRPC8 in autosomal dominant retinitis pigmentosa (RP13). Hum Mol Genet. 2001 Jul 15;10(15):1555-62. PMID:11468273
