Sandbox Reserved 1578

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== Structural highlights ==
== Structural highlights ==
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<scene name='82/824623/Helix_interaction/2'>Helix Interaction</scene> <scene name='82/824623/Nitrogenous_base_interactions/2'>Nitrogenous Base Interaction</scene>
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<scene name='82/824623/Helix_interaction/2'>Helix Interaction</scene> <scene name='82/824623/Nitrogenous_base_interactions/3'>Nigrogenous Base Interaction</scene>
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Revision as of 16:39, 29 November 2019

This Sandbox is Reserved from September 14, 2021, through May 31, 2022, for use in the class Introduction to Biochemistry taught by User:John Means at the University of Rio Grande, Rio Grande, OH, USA. This reservation includes 5 reserved sandboxes (Sandbox Reserved 1590 through Sandbox Reserved 1594).
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
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More help: Help:Editing. For an example of a student Proteopedia page, please see Photosystem II, Tetanospasmin, or Guanine riboswitch.

Contents

SAM Riboswith (2GIS)

SAM Riboswitch

Drag the structure with the mouse to rotate

S-adenosylmethionine (SMA) is a riboswitch, which are structured noncoding RNA domains that selectively bind metabolites and control gene expression. Nearly all examples of the known riboswitches reside in noncoding regions of messenger RNAs where they control transcription or translation.


Function

Stable binding of SAM when adequate amounts are present results in it acting as a transcriptional terminator which turns off gene expression. To understand the function and specificity of SAM as a riboregulator it is important to first understand the key structures of SAM. The key architecture of SAM is composed of ligand-induced interactions between one helix and the 3' side of another helix surrounding the SAM ligand as well as hydrogen bonding interactions between the adenosine base of SAM and interactions between the main chain atoms of methionine with nucleotide interactions.

The adenine base of SAM, A45 and U57, creates a hydrogen bonding interaction to


Relevance

Structural highlights

</StructureSection>

References

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