Sandbox Reserved 1580
From Proteopedia
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The crystal structure of ligand-free E. coli glutaminyl-tRNA synthetase at 2.4 A shows substrate binding is needed to construct a catalytically proficient active site. <ref name=Aminoacyl>12737824</ref> The backbone atoms of 94 amino acid residues, <scene name='82/824625/Backbone_atoms_amino_acid_comp/1'>25–31, 36–63, 77–99, 213–239, and 252–260</scene> could be superimposed on their counterparts showing similarities close to each other. <ref name=Aminoacyl>12737824</ref> One of the amino acids in the <scene name='82/824625/Loop_compromising_amino_acids/1'>surface loop compromising amino acids 64-76</scene> of the dinucleotide fold adopts a new arrangement in the unligand enzyme. <ref name=Aminoacyl>12737824</ref> | The crystal structure of ligand-free E. coli glutaminyl-tRNA synthetase at 2.4 A shows substrate binding is needed to construct a catalytically proficient active site. <ref name=Aminoacyl>12737824</ref> The backbone atoms of 94 amino acid residues, <scene name='82/824625/Backbone_atoms_amino_acid_comp/1'>25–31, 36–63, 77–99, 213–239, and 252–260</scene> could be superimposed on their counterparts showing similarities close to each other. <ref name=Aminoacyl>12737824</ref> One of the amino acids in the <scene name='82/824625/Loop_compromising_amino_acids/1'>surface loop compromising amino acids 64-76</scene> of the dinucleotide fold adopts a new arrangement in the unligand enzyme. <ref name=Aminoacyl>12737824</ref> | ||
== Mutations == | == Mutations == | ||
| - | Mutations in the coding of glutaminyl-tRNA synthetase can cause seizures especially in infants. <ref name=Atrophy>24656866</ref> The mutations in the coding can cause progressive microcephaly and the tissue of the brain to waste away in several different regions including the cerebellar vermis, cerebral cortex, and the cerebellar hemispheres. <ref name=Atrophy>24656866</ref> Progressive microcephaly is a condition that involves mutations in gene coding of brain survival. <ref name=Atrophy>24656866</ref> | + | Mutations in the coding of glutaminyl-tRNA synthetase can cause seizures especially in infants. <ref name=Atrophy>24656866</ref> The mutations in the coding can cause progressive microcephaly and the tissue of the brain to waste away in several different regions including the cerebellar vermis, cerebral cortex, and the cerebellar hemispheres. <ref name=Atrophy>24656866</ref> Progressive microcephaly is a condition that involves mutations in gene coding of brain survival. <ref name=Atrophy>24656866</ref> Seizures are severe but not very common compared to the other disorders. <ref name=Atrophy>24656866</ref> Glutaminyl-tRNA synthetase is important during the brain development stages. <ref name=Atrophy>24656866</ref> |
Revision as of 22:32, 29 November 2019
| This Sandbox is Reserved from September 14, 2021, through May 31, 2022, for use in the class Introduction to Biochemistry taught by User:John Means at the University of Rio Grande, Rio Grande, OH, USA. This reservation includes 5 reserved sandboxes (Sandbox Reserved 1590 through Sandbox Reserved 1594). |
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Glutaminyl-tRNA Synthetase
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References
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