Sandbox Reserved 1588
From Proteopedia
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== FhaC membrane transporter == | == FhaC membrane transporter == | ||
<StructureSection load='4QKY' size='340' side='right' caption='FhaC membrane transporter' scene=''> | <StructureSection load='4QKY' size='340' side='right' caption='FhaC membrane transporter' scene=''> | ||
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== Function == | == Function == | ||
| - | FhaC membrane transporter is a protein in the Omp85 family. It involves two polypeptide-transport associated (POTRA) domains, which are involved in substrate recognition. This protein's main function is to aid in FHA, or filamentous hemagglutinin, secretion. This is carried out by a two-partner secretion system, where FhaC is the translocase and FHA is the substrate. <ref>PMID:26058369</ref> | + | FhaC membrane transporter is a protein in the Omp85 family. It involves two polypeptide-transport associated (POTRA) domains, which are involved in substrate recognition. This protein's main function is to aid in FHA, or filamentous hemagglutinin, secretion. This is carried out by a two-partner secretion system, where FhaC is the translocase and FHA is the substrate. The beta-barrel conformation provides the pore for FHA transport through the membrane of the cell. The substrate is involved in a competitive mechanism with a linker protein, H1 helix, that normally rests inside of the barrel to block transport. This helix interacts weakly with the POTRA2 domain, to sit inside the pore. When the substrate (FHA) arrives at the transport site, it competes with the linker protein for the interaction with the POTRA2 domain. This pushes the H1 helix out, allowing the pore to be used for FHA secretion. <ref>PMID:26058369</ref> |
== Disease == | == Disease == | ||
Revision as of 15:23, 30 November 2019
| This Sandbox is Reserved from September 14, 2021, through May 31, 2022, for use in the class Introduction to Biochemistry taught by User:John Means at the University of Rio Grande, Rio Grande, OH, USA. This reservation includes 5 reserved sandboxes (Sandbox Reserved 1590 through Sandbox Reserved 1594). |
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FhaC membrane transporter
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References
- ↑ Maier T, Clantin B, Gruss F, Dewitte F, Delattre AS, Jacob-Dubuisson F, Hiller S, Villeret V. Conserved Omp85 lid-lock structure and substrate recognition in FhaC. Nat Commun. 2015 Jun 10;6:7452. doi: 10.1038/ncomms8452. PMID:26058369 doi:http://dx.doi.org/10.1038/ncomms8452
