1a0o
From Proteopedia
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[[Image:1a0o.gif|left|200px]] | [[Image:1a0o.gif|left|200px]] | ||
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'''CHEY-BINDING DOMAIN OF CHEA IN COMPLEX WITH CHEY''' | '''CHEY-BINDING DOMAIN OF CHEA IN COMPLEX WITH CHEY''' | ||
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[[Category: Samama, J P.]] | [[Category: Samama, J P.]] | ||
[[Category: Welch, M.]] | [[Category: Welch, M.]] | ||
| - | [[Category: | + | [[Category: Bacterial chemotaxis]] |
| - | [[Category: | + | [[Category: Histidine kinase]] |
| - | [[Category: | + | [[Category: Response regulator]] |
| - | [[Category: | + | [[Category: Signal transduction]] |
| - | [[Category: | + | [[Category: Two-component system]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:38:09 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:38, 2 May 2008
CHEY-BINDING DOMAIN OF CHEA IN COMPLEX WITH CHEY
Overview
Bacterial adaptation to the environment is accomplished through the coordinated activation of specific sensory receptors and signal processing proteins. Among the best characterized of these pathways are those which employ the two-component paradigm. In these systems, signal transmission is mediated by Mg(2+)-dependent phospho-relay reactions between histidine auto-kinases and phospho-accepting receiver domains in response-regulator proteins. Although this mechanism of activation is common to all response-regulators, detrimental cross-talk between different two-component pathways within the same cell is minimized through the use of specific recognition domains. Here, we report the crystal structure, at 2.95 A resolution, of the response regulator of bacterial chemotaxis, CheY, bound to the recognition domain from its cognate histidine kinase, CheA. The structure suggests that molecular recognition, in this low affinity complex (KD = 2 microM), may also contribute to the mechanism of CheY activation.
About this Structure
1A0O is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structure of the CheY-binding domain of histidine kinase CheA in complex with CheY., Welch M, Chinardet N, Mourey L, Birck C, Samama JP, Nat Struct Biol. 1998 Jan;5(1):25-9. PMID:9437425 Page seeded by OCA on Fri May 2 09:38:09 2008
