6n7e
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the cytosolic domain of human CNNM2 in complex with AMP-PNP and Mg2+== | |
| - | + | <StructureSection load='6n7e' size='340' side='right'caption='[[6n7e]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6n7e]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N7E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6mn6|6mn6]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n7e OCA], [http://pdbe.org/6n7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n7e RCSB], [http://www.ebi.ac.uk/pdbsum/6n7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n7e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN]] Familial primary hypomagnesemia with normocalcuria and normocalcemia. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN]] Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen, Y S]] | ||
| + | [[Category: Gehring, K]] | ||
| + | [[Category: Atp-bound]] | ||
| + | [[Category: Closed conformation]] | ||
| + | [[Category: Cnnm2]] | ||
| + | [[Category: Cyclic nucleotide-binding homology domain]] | ||
| + | [[Category: Cystathionine-beta-synthase domain]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Metal transport]] | ||
| + | [[Category: Mg2+ transporter]] | ||
Revision as of 08:10, 4 December 2019
Crystal structure of the cytosolic domain of human CNNM2 in complex with AMP-PNP and Mg2+
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