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5wlo
From Proteopedia
(Difference between revisions)
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==a novel 13-ring macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands== | ==a novel 13-ring macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands== | ||
| - | <StructureSection load='5wlo' size='340' side='right' caption='[[5wlo]], [[Resolution|resolution]] 1.27Å' scene=''> | + | <StructureSection load='5wlo' size='340' side='right'caption='[[5wlo]], [[Resolution|resolution]] 1.27Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5wlo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WLO FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5wlo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WLO FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GR7:(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl+{(2S,3R)-3-hydroxy-4-[(7E)-13-methoxy-1,1-dioxo-1,4,5,6,9,11-hexahydro-10,1lambda~6~,2-benzoxathiazacyclotridecin-2(3H)-yl]-1-phenylbutan-2-yl}carbamate'>GR7</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GR7:(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl+{(2S,3R)-3-hydroxy-4-[(7E)-13-methoxy-1,1-dioxo-1,4,5,6,9,11-hexahydro-10,1lambda~6~,2-benzoxathiazacyclotridecin-2(3H)-yl]-1-phenylbutan-2-yl}carbamate'>GR7</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3i6o|3i6o]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3i6o|3i6o]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wlo OCA], [http://pdbe.org/5wlo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wlo RCSB], [http://www.ebi.ac.uk/pdbsum/5wlo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wlo ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wlo OCA], [http://pdbe.org/5wlo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wlo RCSB], [http://www.ebi.ac.uk/pdbsum/5wlo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wlo ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Agniswamy, J]] | [[Category: Agniswamy, J]] | ||
[[Category: Wang, Y F]] | [[Category: Wang, Y F]] | ||
Revision as of 09:42, 4 December 2019
a novel 13-ring macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands
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