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6mzn

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Revision as of 10:26, 4 December 2019

Zebrafish betaglycan orphan domain structure from tetragonal crystal form

Structural highlights

6mzn is a 1 chain structure with sequence from Brachidanio rerio. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	tgfbr3 (Brachidanio rerio)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

Betaglycan (BG) and endoglin (ENG), homologous co-receptors of the TGF-beta family, potentiate the signaling activity of TGF-beta2 and inhibin A, and BMP-9 and BMP-10, respectively. BG exists as monomer and forms 1:1 growth factor (GF) complexes, while ENG exists as a dimer and forms 2:1 GF complexes. Herein, the structure of the BG orphan domain (BGO) reveals an insertion that blocks the region that the endoglin orphan domain (ENGO) uses to bind BMP-9, preventing it from binding in the same manner. Using binding studies with domain-deleted forms of TGF-beta and BGO, as well as small-angle X-ray scattering data, BGO is shown to bind its cognate GF in an entirely different manner compared with ENGO. The alternative interfaces likely engender BG and ENG with the ability to selectively bind and target their cognate GFs in a unique temporal-spatial manner, without interfering with one another or other TGF-beta family GFs.

Structural Adaptation in Its Orphan Domain Engenders Betaglycan with an Alternate Mode of Growth Factor Binding Relative to Endoglin.,Kim SK, Whitley MJ, Krzysiak TC, Hinck CS, Taylor AB, Zwieb C, Byeon CH, Zhou X, Mendoza V, Lopez-Casillas F, Furey W, Hinck AP Structure. 2019 Jul 16. pii: S0969-2126(19)30231-X. doi:, 10.1016/j.str.2019.06.010. PMID:31327662^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Kim SK, Whitley MJ, Krzysiak TC, Hinck CS, Taylor AB, Zwieb C, Byeon CH, Zhou X, Mendoza V, Lopez-Casillas F, Furey W, Hinck AP. Structural Adaptation in Its Orphan Domain Engenders Betaglycan with an Alternate Mode of Growth Factor Binding Relative to Endoglin. Structure. 2019 Jul 16. pii: S0969-2126(19)30231-X. doi:, 10.1016/j.str.2019.06.010. PMID:31327662 doi:http://dx.doi.org/10.1016/j.str.2019.06.010

1 Structural highlights
2 Publication Abstract from PubMed
3 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6mzn"

@@ Line 3: / Line 3: @@
 <StructureSection load='6mzn' size='340' side='right'caption='[[6mzn]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6mzn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MZN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6mzn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MZN FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mzn OCA], [http://pdbe.org/6mzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mzn RCSB], [http://www.ebi.ac.uk/pdbsum/6mzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mzn ProSAT]</span></td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tgfbr3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mzn OCA], [http://pdbe.org/6mzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mzn RCSB], [http://www.ebi.ac.uk/pdbsum/6mzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mzn ProSAT]</span></td></tr>
 </table>
 <div style="background-color:#fffaf0;">
@@ Line 19: / Line 20: @@
 __TOC__
 </StructureSection>
+[[Category: Brachidanio rerio]]
 [[Category: Large Structures]]
 [[Category: Hinck, A P]]

6mzn

From Proteopedia

Revision as of 10:26, 4 December 2019

Zebrafish betaglycan orphan domain structure from tetragonal crystal form

Structural highlights

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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