Proto-oncogene serine/threonine-protein kinase
From Proteopedia
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**[[1xws]], [[4dtk]], [[4as0]], [[4alu]], [[4alv]], [[4alw]], [[4bzn]], [[4bzo]], [[6bsk]], [[5v80]], [[5toe]], [[5tex]], [[5tel]], [[5o11]], [[5o12]], [[5o13]] – hPim1 kinase domain + inhibitor <br /> | **[[1xws]], [[4dtk]], [[4as0]], [[4alu]], [[4alv]], [[4alw]], [[4bzn]], [[4bzo]], [[6bsk]], [[5v80]], [[5toe]], [[5tex]], [[5tel]], [[5o11]], [[5o12]], [[5o13]] – hPim1 kinase domain + inhibitor <br /> | ||
**[[6ayd]] – hPim1 kinase domain (mutant)+ inhibitor <br /> | **[[6ayd]] – hPim1 kinase domain (mutant)+ inhibitor <br /> | ||
| - | **[[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw], [[3vbx]], [[3vby]], [[3vc4]], [[3umx]], [[4enx]], [[4eny]], [[3umw]], [[4ll5]], [[4lm5]], [[3c4e]], [[5vuc]], [[5vub]], [[5vua]], [[4n70]], [[4n6z]], [[4n6y]], [[4mta]], [[4med]], [[4mbl]], [[4mbi]], [[4lmu]], [[4k1b]], [[4k18]], [[4k0y]], [[4iaa]], [[4i41]], [[6mt0]] – hPim1 catalytic domain + inhibitor <br /> | + | **[[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw]], [[3vbx]], [[3vby]], [[3vc4]], [[3umx]], [[4enx]], [[4eny]], [[3umw]], [[4ll5]], [[4lm5]], [[3c4e]], [[5vuc]], [[5vub]], [[5vua]], [[4n70]], [[4n6z]], [[4n6y]], [[4mta]], [[4med]], [[4mbl]], [[4mbi]], [[4lmu]], [[4k1b]], [[4k18]], [[4k0y]], [[4iaa]], [[4i41]], [[6mt0]] – hPim1 catalytic domain + inhibitor <br /> |
**[[2j2i]], [[3we8]] – hPim1 catalytic domain (mutant)+ inhibitor <br /> | **[[2j2i]], [[3we8]] – hPim1 catalytic domain (mutant)+ inhibitor <br /> | ||
**[[5tur]] - hPim1 + inhibitor <br /> | **[[5tur]] - hPim1 + inhibitor <br /> | ||
Revision as of 10:34, 4 December 2019
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3D Structures of pim-1
Updated on 04-December-2019
References
- ↑ Bachmann M, Moroy T. The serine/threonine kinase Pim-1. Int J Biochem Cell Biol. 2005 Apr;37(4):726-30. PMID:15694833 doi:http://dx.doi.org/10.1016/j.biocel.2004.11.005
- ↑ Brault L, Menter T, Obermann EC, Knapp S, Thommen S, Schwaller J, Tzankov A. PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma. Br J Cancer. 2012 Jul 24;107(3):491-500. doi: 10.1038/bjc.2012.272. Epub 2012 Jun, 21. PMID:22722314 doi:http://dx.doi.org/10.1038/bjc.2012.272
- ↑ Weirauch U, Beckmann N, Thomas M, Grunweller A, Huber K, Bracher F, Hartmann RK, Aigner A. Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma. Neoplasia. 2013 Jul;15(7):783-94. PMID:23814490
- ↑ Huber K, Brault L, Fedorov O, Gasser C, Filippakopoulos P, Bullock AN, Fabbro D, Trappe J, Schwaller J, Knapp S, Bracher F. 7,8-Dichloro-1-oxo-beta-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes. J Med Chem. 2012 Jan 12;55(1):403-13. Epub 2012 Jan 3. PMID:22136433 doi:10.1021/jm201286z
