1a1q

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[[Image:1a1q.gif|left|200px]]
[[Image:1a1q.gif|left|200px]]
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{{Structure
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|PDB= 1a1q |SIZE=350|CAPTION= <scene name='initialview01'>1a1q</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1a1q", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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|GENE= CDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
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{{STRUCTURE_1a1q| PDB=1a1q | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a1q OCA], [http://www.ebi.ac.uk/pdbsum/1a1q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a1q RCSB]</span>
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'''HEPATITIS C VIRUS NS3 PROTEINASE'''
'''HEPATITIS C VIRUS NS3 PROTEINASE'''
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[[Category: Parge, H E.]]
[[Category: Parge, H E.]]
[[Category: Wickersham, J A.]]
[[Category: Wickersham, J A.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: serine protease]]
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[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:40:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:31:16 2008''
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Revision as of 06:40, 2 May 2008

Image:1a1q.gif

Template:STRUCTURE 1a1q

HEPATITIS C VIRUS NS3 PROTEINASE


Overview

During replication of hepatitis C virus (HCV), the final steps of polyprotein processing are performed by a viral proteinase located in the N-terminal one-third of nonstructural protein 3. The structure of NS3 proteinase from HCV BK strain was determined by X-ray crystallography at 2.4 angstrom resolution. NS3P folds as a trypsin-like proteinase with two beta barrels and a catalytic triad of His-57, Asp-81, Ser-139. The structure has a substrate-binding site consistent with the cleavage specificity of the enzyme. Novel features include a structural zinc-binding site and a long N-terminus that interacts with neighboring molecules by binding to a hydrophobic surface patch.

About this Structure

1A1Q is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site., Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, Adachi T, Hostomska Z, Cell. 1996 Oct 18;87(2):331-42. PMID:8861916 Page seeded by OCA on Fri May 2 09:40:30 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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