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6ufh

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ufh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ufh OCA], [http://pdbe.org/6ufh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ufh RCSB], [http://www.ebi.ac.uk/pdbsum/6ufh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ufh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ufh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ufh OCA], [http://pdbe.org/6ufh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ufh RCSB], [http://www.ebi.ac.uk/pdbsum/6ufh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ufh ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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T-box riboregulators are a class of cis-regulatory RNAs that govern the bacterial response to amino acid starvation by binding, decoding and reading the aminoacylation status of specific transfer RNAs. Here we provide a high-resolution crystal structure of a full-length T-box from Mycobacterium tuberculosis that explains tRNA decoding and aminoacylation sensing by this riboregulator. Overall, the T-box consists of decoding and aminoacylation sensing modules bridged by a rigid pseudoknot structure formed by the mid-region domains. Stem-I and the Stem-II S-turn assemble a claw-like decoding module, while the antiterminator, Stem-III, and the adjacent linker form a tightly interwoven aminoacylation sensing module. The uncharged tRNA is selectively recognized by an unexpected set of favorable contacts from the linker region in the aminoacylation sensing module. A complex structure with a charged tRNA mimic shows that the extra moiety dislodges the linker, which is indicative of the possible chain of events that lead to alternative base-pairing and altered expression output.
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Structural basis for tRNA decoding and aminoacylation sensing by T-box riboregulators.,Battaglia RA, Grigg JC, Ke A Nat Struct Mol Biol. 2019 Nov 18. pii: 10.1038/s41594-019-0327-6. doi:, 10.1038/s41594-019-0327-6. PMID:31740853<ref>PMID:31740853</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6ufh" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Revision as of 10:59, 4 December 2019

Co-crystal structure of M. tuberculosis ileS T-box in complex with tRNA-3'-2'3'cyclic phosphate

PDB ID 6ufh

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