1a1r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1a1r.gif|left|200px]]
[[Image:1a1r.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1a1r |SIZE=350|CAPTION= <scene name='initialview01'>1a1r</scene>, resolution 2.5&Aring;
+
The line below this paragraph, containing "STRUCTURE_1a1r", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Active+Site,+Molecule+A'>AC1</scene>, <scene name='pdbsite=AC2:Active+Site,+Molecule+B'>AC2</scene>, <scene name='pdbsite=ZN1:Zn+Binding+Site,+Molecule+A'>ZN1</scene> and <scene name='pdbsite=ZN2:Zn+Binding+Site,+Molecule+B'>ZN2</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= NS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1a1r| PDB=1a1r | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a1r OCA], [http://www.ebi.ac.uk/pdbsum/1a1r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a1r RCSB]</span>
+
-
}}
+
'''HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX'''
'''HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX'''
Line 40: Line 37:
[[Category: Rice, C M.]]
[[Category: Rice, C M.]]
[[Category: Thomson, J A.]]
[[Category: Thomson, J A.]]
-
[[Category: cofactor peptide]]
+
[[Category: Cofactor peptide]]
-
[[Category: helicase]]
+
[[Category: Helicase]]
-
[[Category: nonstructural protein]]
+
[[Category: Nonstructural protein]]
-
[[Category: serine protease]]
+
[[Category: Serine protease]]
-
[[Category: viral protein]]
+
[[Category: Viral protein]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:40:46 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:31:13 2008''
+

Revision as of 06:40, 2 May 2008

Image:1a1r.gif

Template:STRUCTURE 1a1r

HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX


Overview

An estimated 1% of the global human population is infected by hepatitis C viruses (HCVs), and there are no broadly effective treatments for the debilitating progression of chronic hepatitis C. A serine protease located within the HCV NS3 protein processes the viral polyprotein at four specific sites and is considered essential for replication. Thus, it emerges as an attractive target for drug design. We report here the 2.5 angstrom resolution X-ray crystal structure of the NS3 protease domain complexed with a synthetic NS4A activator peptide. The protease has a chymotrypsin-like fold and features a tetrahedrally coordinated metal ion distal to the active site. The NS4A peptide intercalates within a beta sheet of the enzyme core.

About this Structure

1A1R is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide., Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA, Cell. 1996 Oct 18;87(2):343-55. PMID:8861917 Page seeded by OCA on Fri May 2 09:40:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a1r"
Personal tools