1qu9

From Proteopedia

(Difference between revisions)

Revision as of 11:36, 4 December 2019

1.2 A CRYSTAL STRUCTURE OF YJGF GENE PRODUCT FROM E. COLI

Structural highlights

1qu9 is a 3 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RIDA_ECOLI] Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities. Involved in the isoleucine biosynthesis (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The YER057c/YIL051c/YjgF protein family is a set of 24 full-length homologs, each approximately 130 residues in length, and each with no known function or relationship to proteins of known structure. To determine the function of this family, the structure of one member--the YjgF protein from Escherichia coli--was solved and refined at a resolution of 1.2 A. The YjgF molecule is a homotrimer with exact threefold symmetry. Its tertiary and quaternary structures are related to that of Bacillus subtilis chorismate mutase, although their active sites are completely different. The YjgF protein has an active site curiously similar to protein tyrosine phosphatases, including a covalently modified cysteine, but it is unlikely to be functionally related. The lessons learned from this attempt to deduce function from structure may be useful to future projects in structural genomics.

A test case for structure-based functional assignment: the 1.2 A crystal structure of the yjgF gene product from Escherichia coli.,Volz K Protein Sci. 1999 Nov;8(11):2428-37. PMID:10595546^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Volz K. A test case for structure-based functional assignment: the 1.2 A crystal structure of the yjgF gene product from Escherichia coli. Protein Sci. 1999 Nov;8(11):2428-37. PMID:10595546

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qu9"

Categories: Escherichia coli | Large Structures | Volz, K | Structural genomic

@@ Line 1: / Line 1: @@
 ==1.2 A CRYSTAL STRUCTURE OF YJGF GENE PRODUCT FROM E. COLI==
-<StructureSection load='1qu9' size='340' side='right' caption='[[1qu9]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
+<StructureSection load='1qu9' size='340' side='right'caption='[[1qu9]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1qu9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QU9 FirstGlance]. <br>
@@ Line 33: / Line 33: @@
 </StructureSection>
 [[Category: Escherichia coli]]
+[[Category: Large Structures]]
 [[Category: Volz, K]]
 [[Category: Structural genomic]]

1qu9

From Proteopedia

Revision as of 11:36, 4 December 2019

1.2 A CRYSTAL STRUCTURE OF YJGF GENE PRODUCT FROM E. COLI

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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