Purine nucleoside phosphorylase

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<scene name='57/573714/Cv/5'>Residues 241-265 of PNP act as a gate that opens upon substrate binding</scene>. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>. <scene name='57/573714/Cv/6'>Active site</scene>.
<scene name='57/573714/Cv/5'>Residues 241-265 of PNP act as a gate that opens upon substrate binding</scene>. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>. <scene name='57/573714/Cv/6'>Active site</scene>.
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 +
==3D structures of purine nucleoside phosphorylase==
 +
[[Purine nucleoside phosphorylase 3D structures]]
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</StructureSection>
</StructureSection>
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*Purine nucleoside phosphorylase binary complex with phosphate
*Purine nucleoside phosphorylase binary complex with phosphate
 +
**[[4gka]] – hPNP (mutant) + phosphate<br />
**[[1a9o]], [[3pnp]], [[4pnp]] – bPNP + phosphate<br />
**[[1a9o]], [[3pnp]], [[4pnp]] – bPNP + phosphate<br />
**[[1qe5]] – CePNP + phosphate - ''Cellulomonas''<br />
**[[1qe5]] – CePNP + phosphate - ''Cellulomonas''<br />
**[[1tcu]] – SmPNP + phosphate <br />
**[[1tcu]] – SmPNP + phosphate <br />
**[[3khs]] – PNP + phosphate – grouper iridovirus<br />
**[[3khs]] – PNP + phosphate – grouper iridovirus<br />
-
**[[4gka]] – hPNP (mutant) + phosphate<br />
 
**[[4m3n]] – MrPNP + phosphate <br />
**[[4m3n]] – MrPNP + phosphate <br />
**[[3ooe]], [[3ooh]] – EcPNP + phosphate <br />
**[[3ooe]], [[3ooh]] – EcPNP + phosphate <br />
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**[[1rfg]] – hPNP + guanosine<br />
**[[1rfg]] – hPNP + guanosine<br />
**[[1yry]], [[3iny]] – hPNP + guanine derivative <br />
**[[1yry]], [[3iny]] – hPNP + guanine derivative <br />
 +
**[[1pwy]], [[1v41]], [[1v45]] – hPNP + antiviral drug <br />
**[[1v48]], [[2ai1]], [[2ai3]], [[3fuc]] – bPNP + guanine derivative <br />
**[[1v48]], [[2ai1]], [[2ai3]], [[3fuc]] – bPNP + guanine derivative <br />
 +
**[[1b8n]] – bPNP + guanine derivative + phosphate<br />
**[[3e9z]] – SmPNP + guanine derivative <br />
**[[3e9z]] – SmPNP + guanine derivative <br />
**[[3iex]] – SmPNP + guanosine<br />
**[[3iex]] – SmPNP + guanosine<br />
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**[[3iom]] – MtPNP + guanine derivative - ''Mycobacterium tuberculosis'' <br />
**[[3iom]] – MtPNP + guanine derivative - ''Mycobacterium tuberculosis'' <br />
**[[5i3c]] - EcPNP + guanine derivative <br />
**[[5i3c]] - EcPNP + guanine derivative <br />
-
**[[1b8n]] – bPNP + guanine derivative + phosphate<br />
 
**[[1c3x]] – CePNP + guanine derivative + phosphate<br />
**[[1c3x]] – CePNP + guanine derivative + phosphate<br />
-
**[[1pwy]], [[1v41]], [[1v45]] – hPNP + antiviral drug <br />
 
*Purine nucleoside phosphorylase complex with inosine and inosine derivatives
*Purine nucleoside phosphorylase complex with inosine and inosine derivatives
**[[1rct]] – hPNP + inosine <br />
**[[1rct]] – hPNP + inosine <br />
 +
**[[1v3q]] – hPNP + anti HIV drug <br />
**[[1a9q]], [[1a9s]] – bPNP + inosine <br />
**[[1a9q]], [[1a9s]] – bPNP + inosine <br />
 +
**[[2ai2]] – bPNP + inosine derivative <br />
 +
**[[1a9t]], [[1a9p]], [[4pnp]] – bPNP + deazainosine + phosphate<br />
**[[3faz]] – SmPNP + inosine <br />
**[[3faz]] – SmPNP + inosine <br />
**[[5tbv]] – SmPNP + tubercidine <br />
**[[5tbv]] – SmPNP + tubercidine <br />
**[[5tbt]] – SmPNP + cytidine <br />
**[[5tbt]] – SmPNP + cytidine <br />
-
**[[2ai2]] – bPNP + inosine derivative <br />
 
**[[1z38]] – TvPNP + inosine <br />
**[[1z38]] – TvPNP + inosine <br />
**[[3uax]] – BcPNP + inosine <br />
**[[3uax]] – BcPNP + inosine <br />
**[[2bsx]] – PfPNP + inosine <br />
**[[2bsx]] – PfPNP + inosine <br />
**[[1z39]] – TvPNP + deoxyinosine <br />
**[[1z39]] – TvPNP + deoxyinosine <br />
-
**[[1a9t]], [[1a9p]], [[4pnp]] – bPNP + deazainosine + phosphate<br />
 
**[[1pr0]] - EcPNP + inosine + phosphate<br />
**[[1pr0]] - EcPNP + inosine + phosphate<br />
-
**[[1v3q]] – hPNP + anti HIV drug <br />
 
*Purine nucleoside phosphorylase complex with xanthine and xanthine derivatives
*Purine nucleoside phosphorylase complex with xanthine and xanthine derivatives
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**[[1pf7]], [[1rr6]], [[1rsz]], [[1rt9]], [[3k8o]], [[3k8q]] – hPNP + transition state analog <br />
**[[1pf7]], [[1rr6]], [[1rsz]], [[1rt9]], [[3k8o]], [[3k8q]] – hPNP + transition state analog <br />
**[[2on6]] – hPNP (mutant) + transition state analog <br />
**[[2on6]] – hPNP (mutant) + transition state analog <br />
 +
**[[2a0w]], [[2a0x]], [[2a0y]], [[2oc4]], [[2oc9]] – hPNP (mutant) + hypoxanthine derivative <br />
 +
**[[2q7o]], [[3phb]] – hPNP + transition state analog + phosphate<br />
 +
**[[4ear]], [[4eb8]] – hPNP (mutant) + transition state analog + phosphate<br />
**[[1vfn]], [[1a9r]] – bPNP + hypoxanthine<br />
**[[1vfn]], [[1a9r]] – bPNP + hypoxanthine<br />
 +
**[[1b8o]], [[1g2o]] – bPNP + hypoxanthine derivative + phosphate<br />
 +
**[[3bgs]] – bPNP + transition state analog + phosphate<br />
**[[3fnq]], [[5tbu]] – SmPNP + hypoxanthine<br />
**[[3fnq]], [[5tbu]] – SmPNP + hypoxanthine<br />
-
**[[3scz]] – MtPNP + hypoxanthine<br />
 
**[[4dab]] – BsPNP + hypoxanthine<br />
**[[4dab]] – BsPNP + hypoxanthine<br />
**[[4uc0]] – PNP + hypoxanthine – ''Agrobacterium vitis''<br />
**[[4uc0]] – PNP + hypoxanthine – ''Agrobacterium vitis''<br />
**[[5ifk]] - PNP + hypoxanthine - ''Kluyveromyces lactis''<br />
**[[5ifk]] - PNP + hypoxanthine - ''Kluyveromyces lactis''<br />
**[[3enz]] – PfPNP + hypoxanthine + ribose + arsenate<br />
**[[3enz]] – PfPNP + hypoxanthine + ribose + arsenate<br />
-
**[[2a0w]], [[2a0x]], [[2a0y]], [[2oc4]], [[2oc9]] – hPNP (mutant) + hypoxanthine derivative <br />
 
**[[5iu6]] - EcPNP + hypoxanthine derivative<br />
**[[5iu6]] - EcPNP + hypoxanthine derivative<br />
**[[3odg]] – YpPNP + xanthine – ''Yersinia pseudotuberculosis''<br />
**[[3odg]] – YpPNP + xanthine – ''Yersinia pseudotuberculosis''<br />
-
**[[1b8o]], [[1g2o]] – bPNP + hypoxanthine derivative + phosphate<br />
 
-
**[[3bgs]] – bPNP + transition state analog + phosphate<br />
 
-
**[[2q7o]], [[3phb]] – hPNP + transition state analog + phosphate<br />
 
-
**[[4ear]], [[4eb8]] – hPNP (mutant) + transition state analog + phosphate<br />
 
**[[3mb8]] – PNP + transition state analog + phosphate – ''Toxoplasma gondii''<br />
**[[3mb8]] – PNP + transition state analog + phosphate – ''Toxoplasma gondii''<br />
 +
**[[3scz]] – MtPNP + hypoxanthine<br />
**[[1n3i]] – MtPNP + deazahypoxanthine + phosphate <br />
**[[1n3i]] – MtPNP + deazahypoxanthine + phosphate <br />
**[[1i80]] – MtPNP + iminoribitol + deazahypoxanthine + phosphate <br />
**[[1i80]] – MtPNP + iminoribitol + deazahypoxanthine + phosphate <br />
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*Purine nucleoside phosphorylase complex with adenine and adenine derivatives
*Purine nucleoside phosphorylase complex with adenine and adenine derivatives
 +
**[[3ggs]] – hPNP (mutant) + adenosine derivative <br />
**[[1odi]] – TtPNP + adenosine <br />
**[[1odi]] – TtPNP + adenosine <br />
-
**[[1z34]], [[1z35]] – TvPNP + adenosine derivative <br />
+
**[[1z34]], [[1z35]], [[1z37]] – TvPNP + adenosine derivative <br />
**[[4ns1]] – PgPNP + adenosine derivative – ''Porphyromonas gingivalis''<br />
**[[4ns1]] – PgPNP + adenosine derivative – ''Porphyromonas gingivalis''<br />
**[[4nsn]] – PgPNP + adenine <br />
**[[4nsn]] – PgPNP + adenine <br />
-
**[[3ggs]] – hPNP (mutant) + adenosine derivative <br />
 
-
**[[1z37]] – TvPNP + adenosine <br />
 
**[[3e9r]], [[5tbs]] – SmPNP + adenine <br />
**[[3e9r]], [[5tbs]] – SmPNP + adenine <br />
 +
**[[3f8w]] – SmPNP + adenosine <br />
**[[4dao]] – BsPNP + adenine <br />
**[[4dao]] – BsPNP + adenine <br />
-
**[[3f8w]] – SmPNP + adenosine <br />
 
**[[1vhw]] – VcPNP + adenosine <br />
**[[1vhw]] – VcPNP + adenosine <br />
**[[3u40]] – EhPNP + adenosine <br />
**[[3u40]] – EhPNP + adenosine <br />
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*Purine nucleoside phosphorylase complex with purine and purine derivatives
*Purine nucleoside phosphorylase complex with purine and purine derivatives
-
**[[1lv8]], [[1lvu]], [[2qpl]] – bPNP + purine derivative <br />
 
**[[3gb9]] – hPNP (mutant) + purine derivative <br />
**[[3gb9]] – hPNP (mutant) + purine derivative <br />
 +
**[[1lv8]], [[1lvu]], [[2qpl]] – bPNP + purine derivative <br />
**[[1fxu]] – bPNP + purine derivative + phosphate<br />
**[[1fxu]] – bPNP + purine derivative + phosphate<br />
**[[1ovg]] - EcPNP (mutant) + purine derivative <br />
**[[1ovg]] - EcPNP (mutant) + purine derivative <br />
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**[[5etj]], [[5ugf]] - hPNP (mutant) + inhibitor + phosphate<br />
**[[5etj]], [[5ugf]] - hPNP (mutant) + inhibitor + phosphate<br />
**[[1z36]] – TvPNP + antibiotic<br />
**[[1z36]] – TvPNP + antibiotic<br />
 +
**[[2i4t]], [[2isc]] – TvPNP + inhibitor + phosphate<br />
**[[3djf]] – SmPNP + inhibitor<br />
**[[3djf]] – SmPNP + inhibitor<br />
**[[3e0q]] – SmPNP + pyrimidine derivative<br />
**[[3e0q]] – SmPNP + pyrimidine derivative<br />
**[[3fb1]] – SmPNP + ribose-1-phosphate <br />
**[[3fb1]] – SmPNP + ribose-1-phosphate <br />
 +
**[[6awe]], [[6axa]], [[6b2l]], [[6b37]], [[6b3l]], [[6b4q]], [[6b4t]], [[6b56]], [[6b6k]], [[6b71]], [[6b7i]], [[6bb7]], [[6bfv]], [[6bhb]], [[6bi1]], [[6bi9]], [[6bif]], [[6bj6]], [[6bj7]] – SmPNP + inhibitor <br />
**[[5ko5]] - SmPNP + cytosine<br />
**[[5ko5]] - SmPNP + cytosine<br />
**[[5ko6]] - SmPNP + cytosine + ribose-1-phosphate<br />
**[[5ko6]] - SmPNP + cytosine + ribose-1-phosphate<br />
**[[1a69]], [[1pr1]] – EcPNP + formycin <br />
**[[1a69]], [[1pr1]] – EcPNP + formycin <br />
**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />
**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />
-
**[[2i4t]], [[2isc]] – TvPNP + inhibitor + phosphate<br />
 
**[[6aqs]]]] – PfPNP (mutant) + inhibitor + phosphate<br />
**[[6aqs]]]] – PfPNP (mutant) + inhibitor + phosphate<br />
 +
**[[3phc]] – PfPNP + inhibitor + phosphate<br />
**[[2p4s]] – PNP + inhibitor + phosphate – ''Anopheles gambiae''<br />
**[[2p4s]] – PNP + inhibitor + phosphate – ''Anopheles gambiae''<br />
**[[3occ]] – YpPNP + inhibitor + phosphate<br />
**[[3occ]] – YpPNP + inhibitor + phosphate<br />
**[[3of3]] – VcPNP + inhibitor + phosphate<br />
**[[3of3]] – VcPNP + inhibitor + phosphate<br />
-
**[[3phc]] – PfPNP + inhibitor + phosphate<br />
 
**[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br />
**[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br />

Revision as of 10:26, 5 December 2019

Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry 1v2h)

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3D structures of purine nucleoside phosphorylase

Updated on 05-December-2019

References

  1. ↑ Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349-425. PMID:11337031
  2. ↑ Markert ML. Purine nucleoside phosphorylase deficiency. Immunodefic Rev. 1991;3(1):45-81. PMID:1931007
  3. ↑ de Azevedo WF Jr, Canduri F, dos Santos DM, Pereira JH, Bertacine Dias MV, Silva RG, Mendes MA, Basso LA, Palma MS, Santos DS. Crystal structure of human PNP complexed with guanine. Biochem Biophys Res Commun. 2003 Dec 19;312(3):767-72. PMID:14680831 doi:10.1016/j.bbrc.2003.10.190

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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