1uzm
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(New page: 200px<br /> <applet load="1uzm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uzm, resolution 1.49Å" /> '''MABA FROM MYCOBACTE...)
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Revision as of 15:41, 29 October 2007
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MABA FROM MYCOBACTERIUM TUBERCULOSIS
Overview
The fatty acid elongation system FAS-II is involved in the biosynthesis of, mycolic acids, which are major and specific long-chain fatty acids of the, cell envelope of Mycobacterium tuberculosis and other mycobacteria, including Mycobacterium smegmatis. The protein MabA, also named FabG1, has, been shown recently to be part of FAS-II and to catalyse the, NADPH-specific reduction of long chain beta-ketoacyl derivatives. This, activity corresponds to the second step of an FAS-II elongation round., FAS-II is inhibited by the antituberculous drug isoniazid through the, inhibition of the 2-trans-enoyl-acyl carrier protein reductase InhA. Thus, the other enzymes making up this enzymatic complex represent potential, targets for designing new antituberculous drugs. The crystal structure of, the ... [(full description)]
About this Structure
1UZM is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with CS as [ligand]. Active as [[1]], with EC number [1.1.1.100]. Full crystallographic information is available from [OCA].
Reference
Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis., Cohen-Gonsaud M, Ducasse S, Hoh F, Zerbib D, Labesse G, Quemard A, J Mol Biol. 2002 Jul 5;320(2):249-61. PMID:12079383
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