Retinoic acid receptor

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 18: Line 18:
The <scene name='51/516466/Cv/4'>all-''trans'' retinoid acid binds to the hydrophobic pocket of RARγ</scene>.<ref>PMID:7501014</ref>
The <scene name='51/516466/Cv/4'>all-''trans'' retinoid acid binds to the hydrophobic pocket of RARγ</scene>.<ref>PMID:7501014</ref>
 +
 +
==3D structures of retinoic acid receptor==
 +
[[Retinoic acid receptor 3D structures]]
 +
</StructureSection>
</StructureSection>
Line 27: Line 31:
*Retinoic acid receptor α
*Retinoic acid receptor α
-
**[[1dkf]] – mRAR LBD + mRXR LBD – mouse<br />
 
**[[1dsz]] - hRAR LBD + hRXR LBD + DNA – human<br />
**[[1dsz]] - hRAR LBD + hRXR LBD + DNA – human<br />
-
**[[4dqm]] - hRAR LBD + coactivator peptide<br />
+
**[[4dqm]] - hRAR LBD + NCOA-1 peptide<br />
**[[5k13]] - hRAR LBD + inhibitor<br />
**[[5k13]] - hRAR LBD + inhibitor<br />
-
**[[3kmr]] - hRAR LBD + coactivator 1 + agonist<br />
+
**[[3kmr]] - hRAR LBD + NCOA-1 + agonist<br />
**[[3kmz]] - hRAR LBD + corepressor + agonist<br />
**[[3kmz]] - hRAR LBD + corepressor + agonist<br />
**[[3a9e]] - hRAR LBD + hRXR LBD + coactivator peptide<br />
**[[3a9e]] - hRAR LBD + hRXR LBD + coactivator peptide<br />
 +
**[[1dkf]] – mRAR LBD + mRXR LBD – mouse<br />
*Retinoic acid receptor β
*Retinoic acid receptor β
**[[1hra]], [[1xap]] – hRAR DBD<br />
**[[1hra]], [[1xap]] – hRAR DBD<br />
-
**[[4dm8]] - hRAR LBD + coactivator peptide + 9-''cis'' retinoic acid<br />
+
**[[4dm8]] - hRAR LBD + NCOA-1 peptide + 9-''cis'' retinoic acid<br />
-
**[[4dm6]] - hRAR LBD + coactivator peptide<br />
+
**[[4dm6]], [[6ssq]] - hRAR LBD + NCOA-1 peptide<br />
-
**[[4jyg]], [[4jyh]], [[4jyi]] - hRAR LBD + coactivator 1 + agonist<br />
+
**[[4jyg]], [[4jyh]], [[4jyi]] - hRAR LBD + NCOA-1 + agonist<br />
**[[1xdk]] - mRAR LBD + mRXR LBD + thyroid receptor associated protein
**[[1xdk]] - mRAR LBD + mRXR LBD + thyroid receptor associated protein

Revision as of 12:25, 11 December 2019

Structure of human retinoic acid receptor γ ligand-binding domain complex with all-trans retinoic acid (PDB entry 2lbd)

Drag the structure with the mouse to rotate

3D structures of retinoic acid receptor

Updated on 11-December-2019

References

  1. ↑ Wu Q, Lin XF, Ye XF, Zhang B, Xie Z, Su WJ. Ubiquitinated or sumoylated retinoic acid receptor alpha determines its characteristic and interacting model with retinoid X receptor alpha in gastric and breast cancer cells. J Mol Endocrinol. 2004 Jun;32(3):595-613. PMID:15171703
  2. ↑ Sommer KM, Chen LI, Treuting PM, Smith LT, Swisshelm K. Elevated retinoic acid receptor beta(4) protein in human breast tumor cells with nuclear and cytoplasmic localization. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8651-6. PMID:10411930
  3. ↑ Johansson HJ, Sanchez BC, Mundt F, Forshed J, Kovacs A, Panizza E, Hultin-Rosenberg L, Lundgren B, Martens U, Mathe G, Yakhini Z, Helou K, Krawiec K, Kanter L, Hjerpe A, Stal O, Linderholm BK, Lehtio J. Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer. Nat Commun. 2013;4:2175. doi: 10.1038/ncomms3175. PMID:23868472 doi:http://dx.doi.org/10.1038/ncomms3175
  4. ↑ Khuri FR, Lotan R, Kemp BL, Lippman SM, Wu H, Feng L, Lee JJ, Cooksley CS, Parr B, Chang E, Walsh GL, Lee JS, Hong WK, Xu XC. Retinoic acid receptor-beta as a prognostic indicator in stage I non-small-cell lung cancer. J Clin Oncol. 2000 Aug;18(15):2798-804. PMID:10920126
  5. ↑ Soprano KJ, Soprano DR. Retinoic acid receptors and cancer. J Nutr. 2002 Dec;132(12):3809S-3813S. PMID:12468629
  6. ↑ Renaud JP, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras D. Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. Nature. 1995 Dec 14;378(6558):681-9. PMID:7501014 doi:http://dx.doi.org/10.1038/378681a0

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Retinoic_acid_receptor"
Personal tools